Bm86 homologues and novel ATAQ proteins with multiple epidermal growth factor (EGF)-like domains from hard and soft ticks.

International Journal for Parasitology
Ard M NijhofFrans Jongejan

Abstract

Tick control on livestock relies principally on the use of acaricides but the development of acaricide resistance and concerns for environmental pollution underscore the need for alternative control methods, for instance through the use of anti-tick vaccines. Two commercial vaccines based on the recombinant Bm86 protein from Rhipicephalus (Boophilus) microplus ticks were developed. Partial protection of the Bm86 vaccine against other Rhipicephalus (Boophilus) and Hyalomma tick species suggests that the efficacy of a Bm86-based vaccine may be enhanced when based on the orthologous recombinant Bm86 antigen. We therefore identified and analysed the Bm86 homologues from species representing the main argasid and ixodid tick genera, including two from the prostriate Ixodes ricinus tick species. A novel protein from metastriate ticks with multiple epidermal growth factor (EGF)-like domains which is structurally related to Bm86 was identified by using a 3' rapid amplification of cDNA ends (3'-RACE) method with a degenerate primer based on a highly conserved region of Bm86 and its orthologues. This second protein was named ATAQ after a part of its signature peptide. Quantitative reverse transcriptase-PCR showed that ATAQ proteins are ex...Continue Reading

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Citations

Jul 10, 2012·Experimental & Applied Acarology·Gerald BarryLesley Bell-Sakyi
Nov 5, 2010·Parasites & Vectors·Jeanne M FreemanPia U Olafson
Mar 19, 2013·International Journal for Parasitology·Christian StutzerChristine Maritz-Olivier
Jul 7, 2012·The Veterinary Journal·Luís F PariziItabajara da Silva Vaz
Dec 3, 2014·Ticks and Tick-borne Diseases·Willem A van ZylChristine Maritz-Olivier
Jul 30, 2014·Parasite Immunology·E J MarrS T G Burgess
Apr 17, 2016·Veterinary Parasitology·André de Abreu Rangel AguirreRenato Andreotti
Apr 19, 2015·Parasites & Vectors·Luís Fernando PariziItabajara da Silva Vaz
Jul 8, 2014·Pharmaceutical Patent Analyst
Dec 3, 2016·PLoS Neglected Tropical Diseases·Daiane P OldigesCarlos E Suarez
Jun 24, 2020·Parasitology Research·Sarah Melissa Lugo-Caro Del CastilloRodolfo Lagunes-Quintanilla
Jan 26, 2021·Ticks and Tick-borne Diseases·Helen Silva RibeiroRodolfo Cordeiro Giunchetti
Jun 13, 2021·The Journal of Biological Chemistry·Stepan S DenisovIngrid Dijkgraaf
Sep 19, 2017·Journal of Proteome Research·Saúl G Martínez-ArzateHumbert González-Díaz

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Methods Mentioned

BETA
dissections
PCR
PCRs
in vitro transcription
glycosylation

Software Mentioned

ClustalW
BLAST
BioEdit
Treecon
Excel
ExPASy
MatGAT
tBLASTn
NetOGlyc
Compute / MW

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