BMAA, Neurodegeneration, and Neuroprotection.

Neurotoxicity Research
Paul Alan Cox

Abstract

In this volume, studies springing from a BMAA symposium held in Salt Lake City, Utah, in April 2019 are presented. Although most studies of neurotoxicity consider the effects of BMAA as an isolated molecule, it is now known that environmental exposures can be to a combination of BMAA-related molecules, including enantiomers, isomers, other co-occurring cyanotoxins, and BMAA carbamates. Within the body, BMAA may exist in equilibrium with α- and β-carbamates formed in the presence of bicarbonate. BMAA and its isomers 2,4-DAB and AEG, accumulate over decades in biocrusts and persist at depths in soil profiles of the Gulf deserts. In Florida, releases of cyanobacterially ladened water from Lake Okeechobee can extend into coastal environments where diatoms and possibly dinoflagellates also produce BMAA and isomers in addition to brevetoxins. Along the African Lake Chad, neurotoxic risks from consumption of dried cyanobacterial cakes may, however, be outweighed by their amino acid addition to otherwise protein-deficient diets. Discrepancies in the detection and quantification of BMAA from different laboratories likely originate in the use of different analytical methods. C-18 columns, used to study derivatized BMAA, can efficiently s...Continue Reading

References

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Jan 23, 2016·Proceedings. Biological Sciences·Paul Alan CoxSandra Anne Banack
Jun 24, 2016·Environment International·Ian T CousinsMichael S McLachlan
Sep 21, 2017·Neurotoxicity Research·J S MetcalfP A Cox
Jul 23, 2019·Toxicon : Official Journal of the International Society on Toxinology·Simoné DowningTimothy Grant Downing
Feb 23, 2020·Journal of Neuropathology and Experimental Neurology·David A DavisDeborah C Mash
Apr 23, 2020·Frontiers in Aging Neuroscience·Daniela Nunes-CostaNuno Empadinhas
Jun 20, 2020·Neurotoxicity Research·Aspassia D ChatziefthimiouPaul Alan Cox
Jun 26, 2020·Toxicon : Official Journal of the International Society on Toxinology·Thomas SchneiderDoug Lobner
Jul 13, 2020·Neurotoxicity Research·J S MetcalfP A Cox

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Citations

Aug 28, 2021·International Journal of Molecular Sciences·Paola SiniClaudia Crosio

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Methods Mentioned

BETA
NMR

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