Bmi-1 absence causes premature brain degeneration.

PloS One
Guangliang CaoDengshun Miao

Abstract

Bmi-1, a polycomb transcriptional repressor, is implicated in cell cycle regulation and cell senescence. Its absence results in generalized astrogliosis and epilepsy during the postnatal development, but the underlying mechanisms are poorly understood. Here, we demonstrate the occurrence of oxidative stress in the brain of four-week-old Bmi-1 null mice. The mice showed various hallmarks of neurodegeneration including synaptic loss, axonal demyelination, reactive gliosis and brain mitochondrial damage. Moreover, astroglial glutamate transporters and glutamine synthetase decreased in the Bmi-1 null hippocampus, which might contribute to the sporadic epileptic-like seizures in these mice. These results indicate that Bmi-1 is required for maintaining endogenous antioxidant defenses in the brain, and its absence subsequently causes premature brain degeneration.

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Citations

Dec 2, 2015·Experimental and Therapeutic Medicine·Yuanqing HuangDengshun Miao
Dec 24, 2015·Frontiers in Cellular Neuroscience·Ai-Sze Ching, Azlina Ahmad-Annuar
Sep 13, 2013·Nature·Maddalena AdornoMichael F Clarke
Jun 30, 2019·International Forum of Allergy & Rhinology·Rhea ChoiBradley J Goldstein
Sep 21, 2017·Basic & Clinical Pharmacology & Toxicology·Yiming WangDingguo Zhang

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Methods Mentioned

BETA
electron microscopy
genotyping

Software Mentioned

Pro Plus
Image

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