BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells

Peptides
Kishio TomaHirofumi Makino

Abstract

The effects of somatostatin analogs and roles of BMP-6 in the regulation of luteinizing hormone (LH) secretion were investigated using mouse gonadotrope LβT2 cells. LH mRNA expression and LH secretion induced by GnRH were suppressed by treatments with somatostatin analogs, including octreotide and pasireotide, in LβT2 cells. Of note, the inhibitory effects of somatostatin analogs on LH secretion were enhanced by the action of BMP-6. BMP-6 increased the expression levels of somatostatin receptor (SSTR)5, suggesting that BMP-6 upregulates SSTR activity that leads to reduction of GnRH-induced LH secretion. In addition, GnRH-induced phosphorylation of MAPKs including ERK, but not P38 or SAPK, was suppressed by pasireotide in the presence of BMP-6. Given that each inhibitor of ERK, JNK or P38 signaling suppressed GnRH-induced LH transcription, MAPKs are individually involved in the induction of LH production by LβT2 cells. Somatostatin analogs also impaired BMP-6-induced Smad1/5/8 phosphorylation by suppressing BMPRs and augmenting Smad6/7 expression. Collectively, the results indicate that somatostatin analogs have dual effects on the modulation of GnRH-induced MAPK signaling and BMP activity. The pituitary BMP system may play a re...Continue Reading

References

Jul 1, 1990·The Journal of Clinical Investigation·J M AlexanderA Klibanski
Nov 1, 1990·Journal of Neurosurgery·L B JacobyR L Martuza
Aug 1, 1995·Endocrine Reviews·T Reisine, G I Bell
Mar 23, 2002·Science·Kathleen M Scully, Michael G Rosenfeld
Jun 25, 2003·Biochemical and Biophysical Research Communications·Masaya TakedaHirofumi Makino
Feb 11, 2004·Endocrine Reviews·Shunichi ShimasakiGregory F Erickson
Oct 31, 2009·Endocrine Journal·Fumio Otsuka
Apr 20, 2010·Molecular and Cellular Endocrinology·Marta LabeurGünter K Stalla
Oct 26, 2010·Molecular and Cellular Endocrinology·Naoko TsukamotoHirofumi Makino
Nov 8, 2011·Molecular and Cellular Endocrinology·Fumio OtsukaHirofumi Makino
May 25, 2013·Molecular and Cellular Endocrinology·Naoko TsukamotoHirofumi Makino
Mar 22, 2014·Journal of Molecular Endocrinology·Daniel Cuevas-Ramos, Maria Fleseriu
Mar 3, 2015·Biochemical and Biophysical Research Communications·Naoko Tsukamoto-YamauchiFumio Otsuka

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Citations

Jun 25, 2019·Frontiers in Endocrinology·Miaolong LuXianquan Zhan
Jul 28, 2021·Molecular and Cellular Endocrinology·Xin-Yue ZhangPeter C K Leung

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