Bmp4 from the optic vesicle specifies murine retina formation

Developmental Biology
Jie HuangDavid C Beebe

Abstract

Previous studies of mouse embryos concluded that after the optic vesicle evaginates from the ventral forebrain and contacts the surface ectoderm, signals from the ectoderm specify the distal region of the optic vesicle to become retina and signals from the optic vesicle induce the lens. Germline deletion of Bmp4 resulted in failure of lens formation. We performed conditional deletion of Bmp4 from the optic vesicle to test the function of Bmp4 in murine eye development. The optic vesicle evaginated normally and contacted the surface ectoderm. Lens induction did not occur. The optic cup failed to form and the expression of retina-specific genes decreased markedly in the distal optic vesicle. Instead, cells in the prospective retina expressed genes characteristic of the retinal pigmented epithelium. We conclude that Bmp4 is required for retina specification in mice. In the absence of Bmp4, formation of the retinal pigmented epithelium is the default differentiation pathway of the optic vesicle. Differences in the signaling pathways required for specification of the retina and retinal pigmented epithelium in chicken and mouse embryos suggest major changes in signaling during the evolution of the vertebrate eye.

References

Jul 1, 1989·Developmental Biology·C M Park, M J Hollenberg
Dec 16, 1998·Genes & Development·Y Furuta, B L Hogan
Jun 8, 2000·Mechanisms of Development·A Vogel-HöpkerD H Rapaport
Jul 23, 2003·Developmental Biology·Jeanette HyerTakashi Mikawa
Sep 24, 2004·Developmental Biology·Ryuichi YamadaNaoki Takahashi
Apr 6, 2005·Developmental Cell·Juan-Ramon Martinez-MoralesJoachim Wittbrodt
Jun 1, 2005·Development, Growth & Differentiation·Hitomi KuroseHideyo Ohuchi
Jul 20, 2006·Genesis : the Journal of Genetics and Development·Eric C SwindellMilan Jamrich
Aug 31, 2007·Development·Frank MüllerAstrid Vogel-Höpker
Dec 20, 2007·Developmental Biology·Yoshiaki NakayamaNobuyuki Itoh
Jan 13, 2011·Developmental Biology·Claudia M GarciaDavid C Beebe
May 5, 2011·Developmental Biology·Jie HuangDavid C Beebe
Jan 26, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tien T LeNadean L Brown
Nov 15, 2013·Development·Jörg SteinfeldAstrid Vogel-Höpker

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Citations

Sep 27, 2015·Developmental Biology·Jie HuangDavid C Beebe
May 9, 2018·PloS One·Rebecca L RauschAmy E Kiernan
Sep 12, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Marcos J CardozoPaola Bovolenta
May 16, 2019·Scientific Reports·Yan ZhangChristine F Wildsoet
Sep 19, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maud ValensiMarc M Abitbol
Feb 14, 2017·Stem Cells Translational Medicine·Parul ChoudharyPaul John Whiting
Mar 31, 2021·Cellular and Molecular Life Sciences : CMLS·Jianyi Lyu, Xiuqian Mu
Jul 7, 2021·Experimental Eye Research·Jody A SummersAndrei V Tkatchenko
Aug 23, 2021·Cellular and Molecular Life Sciences : CMLS·Tess A V AfanasyevaRob W J Collin

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