BMP4 plays a key role in left-right patterning in chick embryos by maintaining Sonic Hedgehog asymmetry

Molecular Cell
A Monsoro-Burq, N Le Douarin

Abstract

In chick embryos, the first signs of left-right asymmetry are detected in Hensen's node, essentially by left-sided Sonic Hedgehog (Shh) expression. After a gap of several hours, SHH induces polarized gene activities in the left paraxial mesoderm. We show that during this time period, BMP4 signaling is necessary and sufficient to maintain Shh asymmetry within the node. SHH and BMP4 proteins negatively regulate each other's transcription, resulting in a strict complementarity between these two gene patterns on each side of the node. Noggin, present in the midline at this stage, limits BMP4 spreading. Moreover, BMP4 is downstream to Activin signals and controls Fgf8. Thus, early BMP4 signaling coordinates left and right pathways in Hensen's node.

References

Jun 29, 1995·Nature·D HenriqueD Ish-Horowicz
Jul 27, 1995·Nature·P A Wilson, A Hemmati-Brivanlou
Oct 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P H Francis-WestP M Brickell
Apr 22, 1994·Cell·A Hemmati-Brivanlou, D A Melton
Oct 29, 1993·Science·T M LambR M Harland
Jun 1, 1996·Mechanisms of Development·Y Watanabe, N M Le Douarin
Feb 1, 1997·Current Opinion in Neurobiology·D C Weinstein, A Hemmati-Brivanlou
Feb 1, 1997·Developmental Biology·Y Sasai, E M De Robertis
Jan 1, 1997·Annual Review of Cell and Developmental Biology·R Harland, J Gerhart
Aug 26, 1998·Cell·R P Harvey
Nov 24, 1998·Trends in Genetics : TIG·A F Ramsdell, H J Yost
Mar 13, 1999·Current Biology : CB·T BoettgerM Kessel
Jun 8, 1999·Developmental Biology·T F SchillingP W Ingham
Aug 17, 1999·Current Opinion in Genetics & Development·J Capdevila, J C lzpisúa Belmonte
Aug 17, 1999·Current Opinion in Genetics & Development·H J Yost
Nov 5, 1999·Molecular Cell·Y OkadaN Hirokawa
Jan 15, 2000·Current Topics in Developmental Biology·A H Monsoro-Burq, N Le Douarin
Mar 15, 2000·Developmental Biology·H ChangM M Matzuk
Apr 25, 2000·Cell·J CapdevilaJ C Izpisúa Belmonte
Oct 12, 2000·Mechanisms of Development·A Monsoro-Burq, N Le Douarin

❮ Previous
Next ❯

Citations

May 6, 2005·Cytokine & Growth Factor Reviews·Satoshi Kishigami, Yuji Mishina
Mar 20, 2004·Trends in Cardiovascular Medicine·Nadira AhmadMichael Rebagliati
Apr 25, 2003·Developmental Biology·Nicolas HollevilleAnne Hélène Monsoro-Burq
Jun 12, 2003·Developmental Biology·Alessandra Granata, Nandita A Quaderi
Jul 9, 2002·Current Opinion in Genetics & Development·Manuel J Aybar, Roberto Mayor
Apr 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jan Schlueter, Thomas Brand
May 6, 2003·Annual Review of Genomics and Human Genetics·Brent W BisgroveH Joseph Yost
Feb 6, 2007·Orphanet Journal of Rare Diseases·Christèle DubourgVéronique David
May 15, 2002·Evolution & Development·Carol PodlasekKevin T McVary
Nov 26, 2009·Neural Networks : the Official Journal of the International Neural Network Society·Carl H Berdahl
Jan 31, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Angela TorloppThomas Brand
Oct 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Naixin LiAndrea Wizenmann
Nov 6, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Xueyan YuYiping Chen
Mar 8, 2005·Gene Expression Patterns : GEP·Alessandra Granata, Nandita A Quaderi
Jan 28, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Rosa Serra, Chenbei Chang
Jun 12, 2004·Biological Reviews of the Cambridge Philosophical Society·Jonathan Cooke
Oct 7, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Emil Aamar, Igor B Dawid
Feb 7, 2012·Developmental Biology·Cécile Milet, Anne H Monsoro-Burq
Aug 7, 2004·Mechanisms of Development·Angel Raya, Juan Carlos Izpisua Belmonte
Nov 13, 2001·Developmental Cell·C V Wright
Mar 20, 2002·Developmental Biology·Sandrine FaureMalcolm Whitman
Apr 1, 2009·Developmental Biology·Akouavi M EzinMarianne Bronner-Fraser
Nov 9, 2004·Developmental Biology·Satoshi KishigamiYuji Mishina
Aug 24, 2004·The Journal of Biological Chemistry·Laurence LeconteSimon Saule
May 8, 2002·Nature Reviews. Molecular Cell Biology·M Angela Nieto
Oct 1, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Emma MonteSarah Franklin
Apr 15, 2005·Development·Norio TakamotoSophia Y Tsai
Aug 23, 2012·Development·Tetsuya Nakamura, Hiroshi Hamada
May 18, 2007·Development·Ana Teresa TavaresJosé António Belo
Feb 3, 2005·Cellular Signalling·Bram De CraeneGeert Berx
Dec 4, 2001·Genes & Development·P W Ingham, A P McMahon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.