BMP6-induced modulation of the tumor micro-milieu

Oncogene
David StieglitzAnja-Katrin Bosserhoff

Abstract

Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro. In line with this, mast cell deficiency accelerated tumor onset and progression in a melanoma mouse model. Analysis of human melanoma tissues revealed a strong negative correlation between melanoma proliferation and mast cell infiltration. This study elucidates a novel role of BMP6-induced modulation of the tumor microenvironment.

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Citations

Nov 7, 2019·Cell Communication and Signaling : CCS·Ulrike NeckmannToril Holien
Jan 3, 2020·Pigment Cell & Melanoma Research·Mirjana GrujicGunnar Pejler
Jun 7, 2019·Pigment Cell & Melanoma Research·Lena FeuererAnja Katrin Bosserhoff
Oct 9, 2019·Oncogenesis·Miriam Martha de JelAnja-Katrin Bosserhoff
May 1, 2021·International Journal of Molecular Sciences·Tom ZimmermannAnja-Katrin Bosserhoff
Oct 29, 2021·Growth Factors·Andrea Marlene García MuroJosefina Yoaly Sánchez López

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Methods Mentioned

BETA
PCR
ELISA
transfection
transgenic
electrophoresis
FCS

Software Mentioned

SPSS
GraphPad Prism
SynTarget
NOKIA Lumia Phone

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