BMP‑6 protects retinal pigment epithelial cells from oxidative stress‑induced injury by inhibiting the MAPK signaling pathways

International Journal of Molecular Medicine
Li ChenYong Liu

Abstract

Worldwide, neovascular age‑related macular degeneration (nAMD) is one of the most common causes of blindness in the elderly. In particular, degeneration of retinal pigment epithelial (RPE) cells represents the main pathological process in the development of nAMD, and oxidative stress serves a major role. The present study aimed to investigate the association between bone morphogenetic protein 6 (BMP‑6) and nAMD. BMP‑6 concentration was significantly reduced in patients with wet nAMD compared with in the control group. Furthermore, the present study investigated the protective effects of BMP‑6 on RPE cells following oxidative stress‑induced injury. Cell Counting Kit‑8 assay and terminal deoxynucleotidyl transferase dUTP nick‑end labeling staining demonstrated that BMP‑6 increased RPE cell viability, which was decreased following treatment with hydrogen peroxide (H2O2), and reduced H2O2‑induced apoptosis. In addition, western blotting revealed that BMP‑6 reversed the decrease in pro‑caspase‑3 levels and the dysregulation of the B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein (Bax) balance caused by H2O2. In addition, alterations in c‑Jun N‑terminal protein kinase (JNK) and p38 mitogen‑activated protein kinase (MAPK) expressi...Continue Reading

References

Feb 14, 2006·Current Molecular Medicine·Yusuke SekineHidenori Ichijo
Sep 22, 2006·Antioxidants & Redox Signaling·James A McCubreyRichard A Franklin
Aug 30, 2007·The Journal of Biological Chemistry·Amy N AbellGary L Johnson
Jan 9, 2008·Apoptosis : an International Journal on Programmed Cell Death·Christoffer TammSandra Ceccatelli
Jan 13, 2009·Free Radical Biology & Medicine·Zhao-yang WangJia Qu
Feb 28, 2009·Free Radical Biology & Medicine·Jidong YanTianhui Zhu
Mar 3, 2009·Nature Genetics·Billy AndriopoulosJodie L Babitt
Mar 3, 2009·Nature Genetics·Delphine MeynardMarie-Paule Roth
Jun 28, 2011·The American Journal of Pathology·Majda HadziahmetovicJoshua L Dunaief
Jan 12, 2012·Neuroscience Bulletin·Shikha SnigdhaCarl W Cotman
Jan 22, 2013·Biochemical Pharmacology·Amitabha BandyopadhyayParitosh Prashar
Sep 2, 2014·The American Journal of Pathology·Liangliang ZhaoJoshua L Dunaief
Nov 12, 2014·International Journal of Molecular Medicine·Chaoqi LiuDing Xu
Apr 6, 2016·Investigative Ophthalmology & Visual Science·Pachiappan ArjunanVadivel Ganapathy
Mar 24, 2017·American Journal of Hematology·Chiara PiubelliDomenico Girelli

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.