BMP9 and BMP10 are critical for postnatal retinal vascular remodeling.

Blood
Nicolas RicardSabine Bailly

Abstract

ALK1 is a type I receptor of the TGF-β family that is involved in angiogenesis. Circulating BMP9 was identified as a specific ligand for ALK1 inducing vascular quiescence. In this work, we found that blocking BMP9 with a neutralizing antibody in newborn mice significantly increased retinal vascular density. Surprisingly, Bmp9-KO mice did not show any defect in retinal vascularization. However, injection of the extracellular domain of ALK1 impaired retinal vascularization in Bmp9-KO mice, implicating another ligand for ALK1. Interestingly, we detected a high level of circulating BMP10 in WT and Bmp9-KO pups. Further, we found that injection of a neutralizing anti-BMP10 antibody to Bmp9-KO pups reduced retinal vascular expansion and increased vascular density, whereas injection of this antibody to WT pups did not affect the retinal vasculature. These data suggested that BMP9 and BMP10 are important in postnatal vascular remodeling of the retina and that BMP10 can substitute for BMP9. In vitro stimulation of endothelial cells by BMP9 and BMP10 increased the expression of genes involved in the Notch signaling pathway (Jagged1, Dll4, Hey1, Hey2, Hes1) and decreased apelin expression, suggesting a possible cross-talk between these pa...Continue Reading

References

Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P OhE Li
Jun 18, 2003·The Journal of Cell Biology·Holger GerhardtChrister Betsholtz
Apr 27, 2005·The Journal of Biological Chemistry·Monica A BrownSenyon Choe
Feb 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·I B LobovS J Wiegand
Feb 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Steven SuchtingAnne Eichmann
Feb 27, 2007·Angiogenesis·Marcus Fruttiger
Jun 15, 2007·Oncogene·S C SorliY Audigier
Mar 1, 2008·Circulation Research·Laurent DavidSabine Bailly
Jul 5, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Atsushi KasaiAkemichi Baba
Mar 13, 2010·Circulation Research·Marwa MahmoudHelen M Arthur
Mar 30, 2010·Journal of Thrombosis and Haemostasis : JTH·S Dupuis-GirodH Plauchu
Apr 22, 2010·Journal of Cell Science·Yuka SuzukiTetsuro Watabe
Sep 28, 2010·Nature Cell Biology·Lars JakobssonHolger Gerhardt
Apr 7, 2011·Blood·Sara I Cunha, Kristian Pietras
Jun 29, 2011·Cellular and Molecular Life Sciences : CMLS·Marie BidartSabine Bailly
Jul 19, 2011·Nucleic Acids Research·Masato MorikawaKohei Miyazono
Mar 17, 2012·Developmental Cell·Bruno LarrivéeAnne Eichmann

❮ Previous
Next ❯

Citations

Oct 12, 2010·Médecine sciences : M/S·Sabine BaillyHenri Plauchu
Oct 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiro YoshimatsuTetsuro Watabe
Mar 29, 2014·International Journal of Molecular Sciences·Blanca HerreraKatja Breitkopf-Heinlein
Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rebecca M BurkeTiffany J Mellott
Oct 1, 2013·Cellular and Molecular Life Sciences : CMLS·Deepak AtriMichael Simons
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hao ChenMinhong Yan
Jun 9, 2014·Trends in Endocrinology and Metabolism : TEM·Laura A DyerCam Patterson
Dec 3, 2014·Expert Reviews in Molecular Medicine·Jose M Muñoz-FelixJose M Lopez-Novoa
Aug 12, 2014·Microvascular Research·Cathy Pichol-ThievendMathias Francois
Sep 24, 2013·Expert Opinion on Investigational Drugs·Lukas Jac HawinkelsPeter Ten Dijke
Jan 30, 2016·Cytokine & Growth Factor Reviews·Amaya García de VinuesaSabine Bailly
Jan 3, 2013·Trends in Genetics : TIG·Karen BeetsAn Zwijsen
Nov 1, 2012·Microvascular Research·Bikram Sharma, Allan R Albig
Nov 26, 2015·Biochimica Et Biophysica Acta·Tilman BorggrefeBenedetto Daniele Giaimo
Aug 9, 2015·Vascular Pharmacology·Vera NovakovaMartin Klabusay
Oct 4, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Leon Jonker
Oct 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Haiming LeiJunjie Lu
May 28, 2013·Biochimica Et Biophysica Acta·María González-NúñezJosé M López-Novoa
Nov 18, 2014·Biochemical Society Transactions·Yi JinLars Jakobsson
Jun 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sandrine LevetSabine Bailly
Jun 18, 2015·Nature Communications·Irene Maria AspalterHolger Gerhardt
Apr 9, 2015·Frontiers in Genetics·Calinda K E DingenoutsWineke Bakker
Mar 13, 2014·Blood·Sanja CosoTatiana V Petrova
Mar 13, 2015·Frontiers in Genetics·Jérémy ThalgottFranck Lebrin
Jan 27, 2015·Frontiers in Genetics·Emmanuelle Tillet, Sabine Bailly
Jun 22, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·D Berfin Azizoglu, Ondine Cleaver
Sep 21, 2016·The Journal of Cell Biology·Nicolas BaeyensMartin A Schwartz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.