BMP9 is a potential therapeutic agent for use in oral and maxillofacial bone tissue engineering.

Biochemical Society Transactions
Liu LiuDingming Huang

Abstract

Oral and maxillofacial surgery is often challenging due to defective bone healing owing to the microbial environment of the oral cavity, the additional involvement of teeth and esthetic concerns. Insufficient bone volume as a consequence of aging and some oral and maxillofacial surgical procedures, such as tumor resection of the jaw, may further impact facial esthetics and cause the failure of certain procedures, such as oral and maxillofacial implantation. Bone morphogenetic protein (BMP) 9 (BMP9) is one of the most effective BMPs to induce the osteogenic differentiation of different stem cells. A large cross-talk network that includes the BMP9, Wnt/β, Hedgehog, EGF, TGF-β and Notch signaling pathways finely regulates osteogenesis induced by BMP9. Epigenetic control during BMP9-induced osteogenesis is mainly dependent on histone deacetylases (HDACs), microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), which adds another layer of complexity. As a result, all these factors work together to orchestrate the molecular and cellular events underlying BMP9-related tissue engineering. In this review, we summarize our current understanding of the SMAD-dependent and SMAD-independent BMP9 pathways, with a particular focus on cross-talk ...Continue Reading

References

Jan 1, 1991·Journal of Periodontology·R A Jaffin, C L Berman
May 1, 1988·Plastic and Reconstructive Surgery·C DahlinS Nyman
Jun 4, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R L JilkaS C Manolagas
Feb 11, 2004·The Journal of Cell Biology·Lukas KennerErwin F Wagner
May 20, 2005·Endocrine Reviews·Katrien JanssensWim Van Hul
Jun 19, 2009·The EMBO Journal·Jae-Hyuck ShimLaurie H Glimcher
Oct 31, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nobuhiro KamiyaYuji Mishina
Mar 10, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lea M GunnellRegis J O'Keefe
Jun 17, 2010·The Journal of Clinical Investigation·Matthew B GreenblattLaurie H Glimcher
Jan 22, 2011·Nature Reviews. Molecular Cell Biology·Roi Avraham, Yosef Yarden
Sep 3, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xianrong ZhangLing Qin
Sep 20, 2011·Molecular Cell·Kevin C Wang, Howard Y Chang
Mar 17, 2012·Developmental Cell·Bruno LarrivéeAnne Eichmann
Jun 8, 2012·Endocrine Journal·Masato YanoHiroshi Kaji
Jun 12, 2012·Cell·Hans Clevers, Roel Nusse
Feb 16, 2013·Expert Opinion on Biological Therapy·Gun-Il Im, You-Jeong Choi
Aug 31, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ning HuWei Huang
Apr 18, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Veronica J Peschansky, Claes Wahlestedt
Nov 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Diana RigueurKaren M Lyons
Jan 9, 2015·Clinical Oral Investigations·Binnaz LeblebiciogluDimitris N Tatakis
Jan 20, 2015·Nature Genetics·Matthew K IyerArul M Chinnaiyan
Feb 18, 2015·Chemical Reviews·He HuangYingming Zhao
Apr 16, 2015·International Journal of Molecular Medicine·Li LiJinyong Luo
Jul 15, 2015·Bone·Elena García-GaretaGordon W Blunn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.