Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing

Molecular Biology of the Cell
Karri PaavonenKari Alitalo

Abstract

The Bmx gene, a member of the Tec family of nonreceptor protein tyrosine kinases, is expressed in arterial endothelium and in certain hematopoietic and epithelial cells. Previous in vitro studies have implicated Bmx signaling in cell migration and survival and suggested that it contributes to the progression of prostate carcinomas. However, the function of Bmx in normal tissues in vivo is unknown. We show here that Bmx expression is induced in skin keratinocytes during wound healing. To analyze the role of Bmx in epidermal keratinocytes in vivo, we generated transgenic mice overexpressing Bmx in the skin. We show that Bmx overexpression accelerates keratinocyte proliferation and wound reepithelialization. Bmx expression also induces chronic inflammation and angiogenesis in the skin, and gene expression profiling suggests that this occurs via cytokine-mediated recruitment of inflammatory cells. Our studies provide the first data on Bmx function in vivo and form the basis of evaluation of its role in epithelial neoplasia.

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Citations

Aug 26, 2006·The Journal of Clinical Investigation·Yun HeWang Min
Oct 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Tanja HolopainenKari Alitalo
Jan 2, 2007·The Spine Journal : Official Journal of the North American Spine Society·Raj D RaoBrian C Cooley
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Jun 27, 2019·Scientific Reports·Hamed Kharrati-KoopaeeAli Esmailizadeh
Nov 26, 2020·International Journal of Molecular Sciences·Justin F CreedenRobert E McCullumsmith
May 18, 2012·Cancer Research·Tanja HolopainenKari Alitalo

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