PMID: 9435604Jan 22, 1998Paper

BNP gene expression is specifically modulated by stretch and ET-1 in a new model of isolated rat atria

The American Journal of Physiology
B G BruneauA J de Bold

Abstract

We have assessed the effects of stretch or endothelin-1 (ET-1) on atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) secretion and gene expression using a new model of isolated right atria from the rat. This model allows for comparatively long-term in vitro study of adult tissue while retaining the anatomic conformation of the atrium. Stretch and ET-1 resulted in a transient stimulation of ANF and BNP secretion, with an initially larger proportional increase in ANF release. Stretch and ET-1 induced a marked increase in BNP gene expression after 1.5 and 4 h, respectively; the increase in BNP mRNA levels was maintained throughout the 8-h experimental period. Stretch and ET-1 also stimulated c-myc and Egr-1 mRNA levels, two markers of mechanical and receptor-mediated transcriptional activation. The selective response of BNP gene to stretch and ET-1 and the distinct responses of ANF and BNP secretion indicate that the atrial cardiocytes have the capability to individually regulate the synthesis of its endocrine products. This suggests that each hormone plays a specific role in the response of the heart to hemodynamic or neuroendocrine imbalances.

References

Feb 1, 1989·Clinical Biochemistry·I R SardaA J de Bold
Jan 1, 1993·Annual Review of Physiology·K R ChienS M Evans
Oct 1, 1996·Pflügers Archiv : European journal of physiology·M LaineM Weckström

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Citations

Mar 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Heidi VierimaaOlli Vuolteenaho
Mar 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Astra I ChangAdolfo J de Bold
Dec 14, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ondrej LisyJohn C Burnett
Oct 27, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Craig S VinchGerard P Aurigemma

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