BNST lesions aggravate behavioral despair but do not impair navigational learning in rats

Brain Research Bulletin
Pinar PezukR Canbeyli

Abstract

The bed nucleus of the stria terminalis (BNST) is a basal forebrain structure involved in many motivational processes closely linked to stress regulation. The present study investigated the effect of bilateral lesions of the BNST in male Wistar rats on behavioral despair and navigational learning in the Morris water maze both of which present stressful challenges. Compared to controls, BNST-lesioned animals displayed longer duration of immobility in the second of two forced swim tests used to assess behavioral despair but performed similarly in the water maze task. The present results indicate strongly that the BNST is involved in the modulation of behavioral despair. Experimentally induced depression by BNST lesions does not impair learning and memory in the water maze suggesting a possible dissociation between BNST-mediated depression and cognitive performance.

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Citations

Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anita J BechtholtIrwin Lucki
Sep 8, 2011·Behavioural Brain Research·Vanessa de Paula SoaresSâmia R L Joca
Jul 30, 2011·The Journal of Comparative Neurology·Lauren A O'Connell, Hans A Hofmann
Feb 13, 2018·Neuroscience Bulletin·Xiaotao Li, Xiang Li
Sep 1, 2009·Experimental Physiology·Carlos C CrestaniFernando M A Correa
Nov 17, 2009·Behavioural Brain Research·R Canbeyli

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