PMID: 6980039May 1, 1982Paper

Bobbing oscillopsia from gentamicin toxicity

British Journal of Audiology
R T Ramsden, P Ackrill

Abstract

A series of 15 patients had been studied, all of whom suffered severe labyrinthine damage from gentamicin. All subjects were patients in a renal unit and had been in renal failure. The antibiotic was administered, either intramuscularly, intravenously or into the dialysate. In most of the patients there was a history of previous or simultaneous administration of another ototoxic agent, either another aminoglycoside, or a loop diuretic. None of the patients developed severe vertigo. They consistently complained, when they eventually were able to get out of bed, a vertical bouncing of their surroundings, when they walked, coinciding with each step. This sensation is made worse if the patient runs, or drives on a bumpy road, and stops as soon as the patient stands still. Caloric tests revealed non-functioning labyrinths on both sides. Gradual improvement in the symptom occurred over a period of months. No cochleotoxic effect was observed. The probable mechanism of this phenomenon is discussed.

References

Jun 1, 1977·The Journal of Laryngology and Otology·D A Moffat, R T Ramsden
Oct 1, 1967·Archives of Neurology·M B Bender, M Feldman
Apr 1, 1971·The Annals of Otology, Rhinology, and Laryngology·A R Maw
Sep 1, 1968·The Journal of Laryngology and Otology·S D Stephens
Dec 1, 1968·Archives of Neurology·A Atkin, M B Bender
Sep 1, 1949·The Annals of Otology, Rhinology, and Laryngology·M R BROWN

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Citations

Aug 1, 1993·The Journal of Laryngology and Otology·B S GendehZ M Zahir
Jun 1, 1989·Antimicrobial Agents and Chemotherapy·R E Brummett, K E Fox
Jan 21, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·David D PothierJohn A Rutka
Feb 12, 2004·Clinical Pharmacokinetics·Lavern M VercaigneJames M Zacharias
Jan 13, 1998·The Journal of Laryngology and Otology·K M GreenJ P de Carpentier
Sep 15, 2020·Ear, Nose, & Throat Journal·Roland HülseAngela Schell
Nov 1, 1994·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·G M HalmagyiS Wade

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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

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