Body adiposity index, lipid accumulation product, and cardiometabolic index reveal the contribution of adiposity phenotypes in the risk of hyperuricemia among Chinese rural population

Clinical Rheumatology
Haoyu WangLijun Zhang

Abstract

Adiposity phenotypes, estimated by higher body adiposity index (BAI), lipid accumulation product (LAP), and cardiometabolic index (CMI), has conferred increased metabolic risk. The relative contribution of BAI, LAP, and CMI in hyperuricemia, however, is unknown. We hypothesized that these obesity indicators would refine identification of hyperuricemia. Information on serum uric acid (SUA), fasting lipid profiles, and body adiposity measures (BAI, LAP, and CMI) were recorded in a cross-sectional population-based sample of 11,102 participants (≥ 35 years old) from China. BAI, LAP, and CMI were strong independent predictors of SUA in both sexes after correction for potential confounders. In multivariable models, odds ratio (OR) for hyperuricemia for 1 SD increment in BAI, LAP, and CMI were 1.361 (95% CI, 1.224-1.513), 1.393 (95% CI, 1.273-1.525), and 1.332 (95% CI, 1.224-1.448) in females, respectively. For males, these adiposity indices corresponded to an increased hyperuricemia risk of 14, 47, and 33%, respectively. Additionally, compared to the bottom category, females with the top quartile of BAI, LAP, and CMI showed higher adjusted odds of having hyperuricemia, with ORs of 2.064, 7.500, and 4.944, respectively. ORs for hyperu...Continue Reading

References

Aug 8, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·P DeurenbergS Guricci
May 27, 2004·Diabetes Care·Alka M KanayaUNKNOWN Health, Aging, and Body Composition (ABC) Study
Jan 22, 2005·Seminars in Nephrology·John Kanellis, Duk-Hee Kang
Sep 11, 2007·Internal Medicine·Miho HikitaTatsuo Hosoya
Mar 22, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Pierre DesprésPaul Poirier
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Feb 4, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D O OkoroduduF Lopez-Jimenez
May 13, 2010·Lipids in Health and Disease·Mohammadreza BozorgmaneshFereidoun Azizi
Mar 5, 2011·Obesity·Richard N BergmanRichard M Watanabe
May 19, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J Gómez-AmbrosiG Frühbeck
Dec 14, 2011·Circulation·Kathryn A Britton, Caroline S Fox
Feb 2, 2013·Current Opinion in Rheumatology·Changgui LiShun-Jen Chang
Aug 6, 2013·The Journal of Biological Chemistry·Yu TsushimaIichiro Shimomura
Sep 10, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ichiro Wakabayashi, Takashi Daimon
Mar 20, 2015·Journal of the American Society of Nephrology : JASN·Marcus E KleberWinfried März
Apr 30, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ichiro WakabayashiHiroyuki Orita
Jul 3, 2015·Journal of Hypertension·Claudio BorghiGiuseppe Mancia
Sep 29, 2015·Arthritis Care & Research·Akiko YamadaTomoshige Hayashi
Apr 30, 2016·International Journal of Cardiology·Zhao LiAbraham Marria Roselle
Jan 14, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marcus Vinicius Nascimento-FerreiraFrancisco Leonardo Torres-Leal
Jul 26, 2017·Lipids in Health and Disease·Neda Seyed-SadjadiRoss Grant

❮ Previous
Next ❯

Citations

Sep 17, 2018·BMC Cardiovascular Disorders·Jian SongHuaiquan Gao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.