Body-Brain Connections: The Effects of Obesity and Behavioral Interventions on Neurocognitive Aging

Frontiers in Aging Neuroscience
Chelsea M StillmanKirk I Erickson

Abstract

Obesity is a growing public health problem in the United States, particularly in middle-aged and older adults. Although the key factors leading to a population increase in body weight are still under investigation, there is evidence that certain behavioral interventions can mitigate the negative cognitive and brain ("neurocognitive") health consequences of obesity. The two primary behaviors most often targeted for weight loss are caloric intake and physical activity. These behaviors might have independent, as well as overlapping/synergistic effects on neurocognitive health. To date obesity is often described independently from behavioral interventions in regards to neurocognitive outcomes, yet there is conceptual and mechanistic overlap between these constructs. This review summarizes evidence linking obesity and modifiable behaviors, such as physical activity and diet, with brain morphology (e.g., gray and white matter volume and integrity), brain function (e.g., functional activation and connectivity), and cognitive function across the adult lifespan. In particular, we review evidence bearing on the following question: Are associations between obesity and brain health in aging adults modifiable by behavioral interventions?

References

Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·M I ChimowitzA J Furlan
Dec 29, 2000·Molecular Psychiatry·L VitkovicC Jacque
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A M Prentice, S A Jebb
Mar 29, 2003·Psychological Science·Stanley Colcombe, Arthur F Kramer
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stanley J ColcombeSteriani Elavsky
May 19, 2004·Archives of Neurology·Marianne J EngelhartMonique M B Breteler
Jan 22, 2005·Science·Michael W Schwartz, Daniel Porte
Mar 18, 2005·Journal of Applied Physiology·Anne Marie W Petersen, Bente Klarlund Pedersen
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
May 4, 2005·Acta Diabetologica·A M Sharma, V T Chetty
Oct 12, 2005·Archives of Neurology·William JagustMary Haan
Feb 17, 2006·Current Opinion in Nephrology and Hypertension·Zdenka Pausova
Mar 21, 2006·NeuroImage·Nicola PannacciulliPietro A Tataranni
Oct 3, 2006·Neurobiology of Aging·Giovanni RavagliaChristopher Patterson
Oct 13, 2006·Neurology·Ian J DearyJohn M Starr
Oct 27, 2006·Diabetes Care·Giovanni RavagliaChristopher Patterson
Nov 30, 2006·Psychosomatic Medicine·Anna L MarslandStephen B Manuck
Dec 15, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stanley J ColcombeArthur F Kramer
Mar 14, 2007·Archives of Neurology·José A LuchsingerRichard Mayeux
Apr 14, 2007·Current Alzheimer Research·Kristine Yaffe
May 12, 2007·Journal of the American Geriatrics Society·Snorri B RafnssonF Gerald R Fowkes
May 31, 2007·The Journal of Clinical Endocrinology and Metabolism·Lauri T HaltiaValtteri Kaasinen
Jul 17, 2007·Trends in Cognitive Sciences·Arthur F Kramer, Kirk I Erickson
Sep 4, 2007·Trends in Neurosciences·Carl W CotmanLori-Ann Christie
Sep 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Angela Fontán-LozanoAngel Manuel Carrión
Dec 21, 2007·Nature Reviews. Neuroscience·Charles H HillmanArthur F Kramer
Mar 12, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M A BeydounY Wang
Jun 3, 2008·Biological Psychiatry·Anna L MarslandAhmad R Hariri
Jul 2, 2008·Diabetes·Beverley BalkauUNKNOWN EGIR-RISC Study Group
Jul 30, 2008·Archives of Internal Medicine·John M JakicicCarol Janney
Oct 15, 2008·The International Journal of Neuroscience·John GunstadEvian Gordon
Oct 18, 2008·British Journal of Sports Medicine·K I Erickson, A F Kramer
Dec 17, 2008·The American Journal of Clinical Nutrition·Séverine SabiaArchana Singh-Manoux

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Citations

May 16, 2018·Journal of Alzheimer's Disease : JAD·Ilse A C ArnoldussenDeborah R Gustafson
Jun 1, 2019·Journal of Magnetic Resonance Imaging : JMRI·Melissa SchallN Jon Shah
Apr 29, 2020·Psychophysiology·Chelsea M StillmanKirk I Erickson
Oct 17, 2018·Proceedings of the National Academy of Sciences of the United States of America·Bruce N Ames
Jun 11, 2019·Frontiers in Neuroscience·Romina María Uranga, Jeffrey Neil Keller
Jun 14, 2019·Frontiers in Neurology·Pauline H CrollMeike W Vernooij
Jan 24, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Mustapha BouhraraRichard G Spencer
Jan 9, 2021·Frontiers in Neuroscience·Pavithra ChandramowlishwaranShanthi Srinivasan
Jul 2, 2018·The Journal of Pediatrics·Olivia LinthavongUNKNOWN Extremely Low Gestational Age Newborn (ELGAN) Research Study
Jun 7, 2018·Cell Metabolism·Mark P Mattson, Thiruma V Arumugam
Jul 21, 2021·Neuroscience and Biobehavioral Reviews·Justine DaoustAndréanne Michaud
Jul 21, 2021·Journal of the American College of Nutrition·Nezire İnceHalit Tanju Besler

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Methods Mentioned

BETA
blood draw

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