Body composition analysis in patients with myotonic dystrophy types 1 and 2

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Stojan PericVidosava Rakocevic-Stojanovic

Abstract

To date, there are only several reports on body composition in myotonic dystrophy type 1 (DM1) and there are no data for myotonic dystrophy type 2 (DM2). The aim was to analyze body composition of patients with DM1 and DM2, and its association with socio-demographic and clinical features of the diseases. There were no statistical differences in sociodemographic features between 20 DM1 patients and 12 DM2 patients. Body composition was assessed by DEXA (dual-energy x-ray absorptiometry). A three-compartment model was used: bone mineral content (BMC), fat mass (FM), and lean tissue mass (LTM). Patients with DM1 and DM2 had similar total body mass (TBM), BMC, FM, and LTM. Patients with DM1 had higher trunk-limb fat index (TLFI) in comparison to DM2 patients which indicates visceral fat deposition in DM1 (1.16 ± 0.32 for DM1 vs. 0.87 ± 0.23 for DM2, p < 0.05). Right ribs bone mineral density was lower in DM2 group (0.68 ± 0.07 g/cm2 vs. 0.61 ± 0.09 g/cm2, p < 0.05). Higher percentage of FM in legs showed correlation with lower strength of the upper leg muscles in DM1 (ρ = - 0.47, p < 0.05). Higher muscle strength in DM2 patients was in correlation with higher bone mineral density (ρ = + 0.62, p < 0.05 for upper arm muscles, ρ = + 0...Continue Reading

References

Jul 28, 2004·The American Journal of Clinical Nutrition·Gianluca PerseghinLivio Luzi
May 17, 2005·Archives of Physical Medicine and Rehabilitation·Susan AitkensMegan A McCrory
Oct 10, 2006·Seminars in Pediatric Neurology·Ulrike Schara, Benedikt G H Schoser
Jun 21, 2008·The New England Journal of Medicine·William J GrohRobert M Pascuzzi
Oct 7, 2009·Acta Neurologica Scandinavica·V Rakocevic StojanovicS Apostolski
Feb 24, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Chris Turner, David Hilton-Jones
Apr 5, 2011·Journal of Neurology·Alide A TielemanBaziel G M van Engelen
Apr 16, 2013·BioMed Research International·Dušanka Savić PavićevićStanka Romac
Jun 12, 2013·Journal of Neurology·Chiara TerraccianoRoberto Massa
Jul 3, 2013·Journal of the Neurological Sciences·E PasseriS Corbetta
May 8, 2015·European Journal of Clinical Investigation·Elena PasseriSabrina Corbetta
Jun 6, 2015·Muscle & Nerve·Chad HeatwoleRichard T Moxley
Jul 18, 2015·Neurological Research·Vidosava Rakocevic-StojanovicIvana Novakovic
Jan 14, 2017·Neuromuscular Disorders : NMD·Saam SedehizadehPaul Maddison
Aug 2, 2017·Journal of Neurology·Stojan PericVidosava Rakocevic-Stojanovic
Dec 1, 2017·Frontiers in Endocrinology·Elena DozioSabrina Corbetta
May 18, 2018·Frontiers in Neurology·Stephan WenningerBenedikt Schoser
Sep 25, 2018·Journal of Neuromuscular Diseases·Ivo BozovicVidosava Rakocevic-Stojanovic
Oct 9, 2018·Frontiers in Neurology·Benedikt Schoser, Giovanni Meola

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Citations

Feb 18, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Antonio Federico
Oct 15, 2020·Acta neurologica Belgica·Sebastiaan DhontEva Van Braeckel
Mar 3, 2021·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Thomas TheodosiouIoannis Zalonis
Jun 27, 2021·BMC Neurology·Fabian HofmeisterMichael Drey
Jun 15, 2021·The Journal of Clinical Endocrinology and Metabolism·Stephen J Winters

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