Body composition and age in African-American and Caucasian women: relationship to plasma leptin levels

Metabolism: Clinical and Experimental
H M PerryG Wittert

Abstract

Leptin is a recently isolated peptide hormone released from adipocytes that has been postulated to play a role in appetite regulation and energy metabolism. Aging affects both food intake and body composition. Body composition is also affected by ethnicity. We have evaluated the relationships between serum leptin levels, age, body composition (by dual-energy x-ray absorptiometry), and hormonal parameters in a cross-sectional study of 94 women, 53 African-American (AAF) and 41 Caucasian (CF). Our hypotheses were as follows: (1) changes in body composition would be related to age in a sinusoidal pattern, (2) changes in serum leptin would parallel changes in body fat, (3) serum leptin levels would be influenced by body fat distribution, and (4) serum leptin would be related to serum concentrations of sex hormones. Serum leptin paralleled changes in body fat and body mass index (BMI) with age. In the entire group, serum leptin correlated closely with measures of body fat, including BMI and total fat mass, and there was no difference in leptin levels between the two ethnic groups. In simple regression analysis, serum leptin was related to both serum estradiol and testosterone. The relationship between serum leptin and trunk fat was ...Continue Reading

Citations

May 16, 2001·Current Rheumatology Reports·H M Perry, J E Morley
Dec 4, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J E Morley
Dec 4, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S E MooreA M Prentice
Mar 5, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John E Morley
Apr 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mauro ZamboniOttavio Bosello
Aug 24, 2004·The American Journal of Clinical Nutrition·Constance E RuhlUNKNOWN Health, Aging, and Body Composition Study
Oct 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John E Morley, Richard N Baumgartner
May 28, 2010·Arthritis and Rheumatism·Jie ZhangUNKNOWN Consortium for the Longitudinal Evaluations of African Americans with Early Rheumatoid Arthritis Investigators
Aug 2, 2015·Age·Adam WysokińskiTomasz Kostka
Jul 30, 1999·The American Journal of Clinical Nutrition·S S Yeh, M W Schuster
Jan 11, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·J E Morley
Jul 16, 2010·Geriatrics & Gerontology International·Saeko Akimoto, Kyoko Miyasaka
Mar 25, 2014·Journal of Clinical Laboratory Analysis·Sara García-JiménezMiguel A Sánchez-Alemán
Jun 21, 2014·Journal of Wildlife Diseases·M Colter ChitwoodChristopher S DePerno
Oct 18, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M B MonroeP P Jones
Mar 30, 1999·The Proceedings of the Nutrition Society·J E Morley
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·D M BermanA P Goldberg
Aug 28, 2001·The American Journal of Clinical Nutrition·C E Ruhl, J E Everhart
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·A M IsidoriA Fabbri
Mar 23, 2000·Eating and Weight Disorders : EWD·P CuginiC Giovannini
Oct 13, 2006·Current Opinion in Gastroenterology·John E Morley
Feb 12, 2009·Infectious Agents and Cancer·Camille C RaginEmanuela Taioli
Nov 23, 2007·Clinical Endocrinology·Massimiliano RuscicaPaolo Magni
Mar 1, 2012·The British Journal of Nutrition·Britta SchautzAnja Bosy-Westphal
Apr 1, 2000·Journal of the American Aging Association·W A Banks, J E Morley
Jun 11, 2002·Annual Review of Nutrition·Barbara A HorwitzRoger B McDonald
Jan 18, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A M TershakovecV A Stallings
Mar 13, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S SöderbergB Ahrén
Sep 10, 2008·Annals of Saudi Medicine·Kamal A Al-ShoumerBagavathy A Vasanthy
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·B A GowerE Kent
Mar 29, 2002·The Journal of Laboratory and Clinical Medicine·Robert FrederichClaire Pomeroy
Nov 5, 2020·The Journal of Sports Medicine and Physical Fitness·İsmail Sariİnayet Güntürk
Oct 27, 1999·Metabolism: Clinical and Experimental·B Fruehwald-SchultesA Peters
Mar 8, 2005·Neurobiology of Aging·Julie A MattisonDonald K Ingram
Aug 4, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Amrita BakshiUmesh Rai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.