Body composition and fuel metabolism after kidney grafting

European Journal of Clinical Investigation
U SteigerF F Horber

Abstract

Kidney transplant patients display decreased muscle mass and increased fat mass. Whether this altered body composition is due to glucocorticoid induced altered fuel metabolism is unclear. To answer this question, 16 kidney transplant patients were examined immediately after kidney transplantation (12 +/- 4 days, mean +/- SEM) and then during months 2, 5, 11 and 16, respectively, by whole body dual energy X-ray absorptiometry (Hologic QDR 1000W) and indirect calorimetry. Results were compared with those of 16 age, sex and body mass index matched healthy volunteers examined only once. All patients received dietary counselling with a step 1 diet of the American Heart Association and were advised to restrict their caloric intake to the resting energy expenditure plus 30%. Immediately after transplantation, lean mass of the trunk was higher by 7 +/- 1% (P < 0.05) and that of the limbs was lower by more than 10% (P < 0.01) in patients than in controls. In contrast, no difference in fat mass and resting energy expenditure could be detected between patients and controls. During the 16 months of observation, total fat mass increased in male (+4.9 +/- 1.5 kg), but not in female patients (0.1 +/- 0.8 kg). The change in fat mass observed i...Continue Reading

References

Jan 1, 1976·Medicine·L Axelrod
Feb 1, 1992·Clinical Endocrinology·W M Bennet, M W Haymond
Mar 1, 1990·The American Journal of Physiology·T M LincolnA E Taylor
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M Rebuffé-ScriveP Björntorp
May 1, 1986·The American Journal of Clinical Nutrition·F F HorberF J Frey
Mar 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W E HoyB M Byer
May 1, 1993·The American Journal of Clinical Nutrition·O L SvendsenC Christiansen

❮ Previous
Next ❯

Citations

Jul 13, 2001·Nutrition·R A RichardsonH I Davidson
Mar 13, 2002·Transplantation·Fabio M UlivieriBruno M Cesana
Mar 10, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Linda OrazioNicole Isbel
Oct 19, 2006·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Karine MoreauMichel Aparicio
May 30, 2015·Diabetes & Metabolism·C VaursP Ritz
Aug 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Wael El HagganMichel Aparicio
Dec 17, 2010·Clinical Transplantation·Liv ForliOystein Bjortuft
May 28, 2011·Acta Physiologica Hungarica·Szilveszter DolgosL Rosivall
Jun 15, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Anne-Elisabeth HengBeatrice Morio
Feb 1, 2017·Nature Reviews. Nephrology·Dorien M ZelleGerjan Navis
May 4, 2001·JPEN. Journal of Parenteral and Enteral Nutrition·J M Hasse
Sep 9, 2008·Scandinavian Journal of Urology and Nephrology·Szilveszter DolgosJens Bollerslev
Feb 14, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·UNKNOWN ASPEN Board of Directors and the Clinical Guidelines Task Force
Mar 16, 2007·Hormone Research·Dominique Simon
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Eugénie C H van den HamJohannes P van Hooff
Sep 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E de PascaleP Castellino
Nov 30, 2019·Frontiers in Nutrition·Ilaria GandolfiniAlice Sabatino
Mar 29, 2016·Therapeutic Drug Monitoring·Elisabet StørsetAnders Åsberg
Jan 3, 2021·International Urology and Nephrology·Jun Young Do, Seok Hui Kang
Feb 24, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Qingqing CaiGerjan J Navis
Jun 7, 2017·Transplantation Proceedings·K Y KimUNKNOWN KNOW-KT Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.