Body composition and metabolic changes associated with massive intestinal resection in mice

Journal of Pediatric Surgery
Niramol TantemsapyaBrad W Warner

Abstract

The specific changes in body composition and metabolism during the adaptation response to massive intestinal loss are presently unclear. The present study was designed to determine alterations in these parameters using an established mouse model. Male C57/Bl6 mice underwent either 50% small bowel resection (SBR) or transection with reanastomosis (Sham) operation. Oxygen consumption per unit time, carbon dioxide production per unit time, respiratory quotient, and energy expenditure were measured by indirect calorimetry along with body composition determination by nuclear magnetic resonance at postoperative days 1, 3, 7, 14, 21, and 28. The mice that underwent SBR had lower rates of metabolism as measured by decreased energy expenditure, carbon dioxide production per unit time and oxygen consumption per unit time when compared with the Sham group throughout the study period. During adaptation, SBR mice had restoration of body fat at two weeks after the operation while the lean mass and body weight remained lower throughout. Without supplemental parenteral nutrition, the adaptation response to massive SBR is characterized by reduced energy metabolism and an inappropriate replenishment of fat stores over lean mass. Futures studies ...Continue Reading

References

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Citations

Jan 22, 2013·Journal of Pediatric Surgery·Brad W Warner
Mar 31, 2015·Journal of Pediatric Surgery·Jose Diaz-MironBrad W Warner
Dec 19, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Raphael C SunBrad W Warner
Sep 4, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·J SommovillaB W Warner
Dec 24, 2013·Journal of Pediatric Gastroenterology and Nutrition·Debora DuroChristopher Duggan
Apr 3, 2012·Journal for Specialists in Pediatric Nursing : JSPN·Karen E Johnson, Lindsay A Taliaferro
Jan 8, 2020·Digestive Diseases and Sciences·Adeeti J ChiplunkerDeborah C Rubin
Mar 14, 2020·Journal of Pediatric Surgery·Emily J OnuferBrad W Warner
Mar 29, 2018·Journal of Pediatric Surgery·Lauren BarronBrad W Warner
Mar 18, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Emily J OnuferBrad W Warner
Mar 6, 2009·Current Opinion in Supportive and Palliative Care

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