Body composition, fatigue and exercise in patients with prostate cancer undergoing androgen-deprivation therapy

BJU International
R U NewtonD R Taaffe

Abstract

To investigate the association between lean mass (LM) and fat mass (FM) with fatigue and vitality before and after exercise in patients with prostate cancer already undergoing androgen-deprivation therapy (ADT). Cross-sectional associations between LM and FM with fatigue and/or vitality measures were examined in 229 patients (aged 43-90 years). Prospective analysis was undertaken in 129 patients who underwent a supervised 3-6 months exercise programme (predominantly resistance + aerobic). Whole body and appendicular LM, and total and trunk FM were assessed by dual X-ray absorptiometry. Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-30) and vitality using the Short Form-36. Based on the EORTC QLQ-30, 19% of patients had clinically relevant fatigue. There was no association between LM and fatigue; however, total (P = 0.013), trunk (P = 0.015) and percentage (P = 0.008) FM were higher in fatigued than not fatigued patients, with total and trunk FM 5.0 and 2.6 kg higher, respectively. For quartiles of vitality, a similar pattern emerged for FM with those in the lowest quartile of vitality having the highest FM values (P = 0.014-0.034). In co...Continue Reading

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Citations

Sep 3, 2019·Journal of Cancer Survivorship : Research and Practice·Anna L RobertsAbigail Fisher
Jul 24, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kim EdmundsRobert U Newton
Aug 10, 2020·Journal of Pain and Symptom Management·Mohammed Al MaqbaliMu'ath Ibrahim Tanash
Oct 4, 2020·Medicine and Science in Sports and Exercise·Rebekah L WilsonDaniel A Galvão

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