Body Composition, Food Intake, and Energy Expenditure in a Murine Model of Roux-en-Y Gastric Bypass Surgery

Obesity Surgery
Zheng HaoHans-Rudolf Berthoud

Abstract

The mechanisms by which Roux-en-Y gastric bypass surgery (RYGB) so effectively lowers body weight and improves glycemic control are not well understood, and murine models are essential for identifying the crucial signaling pathways involved. The aim of this study is to characterize the time course of RYGB on body weight, body composition, food intake, and energy expenditure in diet-induced obese mice and establish a tissue bank for global "omics" or targeted biochemical and structural analyses. High-fat diet-induced obese mice were subjected to RYGB using an improved surgical technique with a small gastric pouch. The effects on body weight, body composition, food intake, and energy expenditure were compared to sham surgery, high-fat diet-restricted weight-matched controls, and never-obese chow-fed controls. Without mortality or complications, RYGB surgery in high-fat diet-induced obese mice gradually decreased body weight to a plateau that was more or less sustained for up to 12 weeks (33 g, -18 %, p < 0.01) and significantly lower compared with sham-operated mice (51 g, +25 %, p < 0.01), but higher (+18 %, p < 0.01) than age-matched, chow-fed control mice (27 g). Energy intake after RYGB was significantly suppressed compared t...Continue Reading

References

Jul 9, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael M MeguidPaul R G Cunningham
Oct 25, 2006·Annals of Surgery·Nicolas V ChristouLloyd D Maclean
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L Sjöström
Sep 4, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Huiyuan ZhengHans-Rudolf Berthoud
Nov 26, 2009·Gastroenterology·Marco BueterCarel W le Roux
Jul 17, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andras HajnalRobert N Cooney
Aug 27, 2010·The American Journal of Clinical Nutrition·Elizabeth A OdstrcilJohn S Fordtran
Jun 23, 2012·Obesity Facts·Joaquin OrtegaVicente Sebastia
Sep 22, 2012·Gastroenterology·Adam P ChambersRandy J Seeley
Dec 12, 2012·Obesity Surgery·David ThivelBlandine Laferrère
Jan 10, 2013·European Journal of Clinical Nutrition·A LaureniusT Olbers
Mar 29, 2013·Science Translational Medicine·Alice P LiouLee M Kaplan
Mar 29, 2014·Nature·Karen K RyanRandy J Seeley
Jul 30, 2014·ACS Chemical Neuroscience·India A ReddyAurelio Galli
Oct 29, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Z HaoJ Ye
Jan 24, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H MünzbergH-R Berthoud
Aug 26, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J B SchmidtA Sjödin

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Citations

Aug 23, 2016·Frontiers in Nutrition·Thomas A Lutz, Marco Bueter
Oct 1, 2016·Molecular Metabolism·Christopher D MorrisonHans-Rudolf Berthoud
Nov 15, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C BlanchardC Le May
Sep 25, 2018·Journal of Clinical Pharmacology·Barbara Ameer, Michael A Weintraub
Mar 19, 2019·Journal of Neuroendocrinology·Darleen A Sandoval
May 28, 2019·Scientific Reports·Michael B MumphreyHans-Rudolf Berthoud
May 12, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sha LeiWei Jia
Jun 11, 2020·EMBO Molecular Medicine·Christopher L AxelrodJohn P Kirwan
Mar 14, 2018·Obesity Surgery·Silvia BettiniLuca Busetto
May 23, 2018·Diabetes·John P KirwanHans-Rudolf Berthoud
Oct 21, 2019·Obesity Surgery·Matthew StevensonLouis Ragolia
May 20, 2020·Frontiers in Endocrinology·Mohammed K Hankir, Florian Seyfried
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marlena M HolterBethany P Cummings
Jul 13, 2017·Current Obesity Reports·Natasha KapoorNeil G Docherty
Jul 5, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Erika TarascoThomas A Lutz
Feb 6, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Presheet P PatkarAndrew C Shin
May 6, 2021·Cell Reports Medicine·Justine FaramiaFrédéric Picard
Jun 6, 2021·Endocrinology·Katharina SchnablMartin Klingenspor

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