Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians: Implications for Osteosarcopenia.

Journal of the American Medical Directors Association
Eleonora PoggiogalleEric Ravussin

Abstract

Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old. Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included. The definition of sarcopenia was based on appendicular lean mass (ALM). Osteoporosis was diagnosed based on bone mineral density (BMD) T score. Four phenotypes were compared: (1) healthy body composition, that is, nonosteoporotic nonsarcopenic (CO, control group), (2) osteoporotic (O, low BMD T score), (3) sarcopenic (S, low ALM), and (4) osteosarcopenic (OS, low BMD T score and low ALM). Sex- and age-specific IGF1-Standard Deviation Scores (SDS) were calculated. The Continuous Scale-Physical Functional Performance (CS-PFP) test was performed. In OS men, IGF1-SDS values (-0.61 ±0.37 vs -0.04 ± 0.52, P = .02) were lower than those in CO males (control group), whereas IGF1-SDS were similar in the 4 body composition phenotypes in women. In men only, ALM was positively associated with IGF1-SDS values (P = .01) independent of age and C-reactive protein concentration. Regarding bone...Continue Reading

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Citations

Sep 16, 2020·International Journal of Environmental Research and Public Health·Myong-Won SeoJong Kook Song
Jul 18, 2020·European Geriatric Medicine·Gabriela Fagundes BelchiorGustavo Duque
Jul 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Maryam KazemiMarla E Lujan
Jan 28, 2021·Nutrients·Tatsuro InoueAtsuhiro Tsubaki
Dec 26, 2018·Journal of the American Medical Directors Association·Philip D SloaneSheryl Zimmerman
Aug 17, 2021·Geriatric Orthopaedic Surgery & Rehabilitation·Stephanie R DayerGohar Azhar

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