Body composition in Nepalese children using isotope dilution: the production of ethnic-specific calibration equations and an exploration of methodological issues

PeerJ
Delan DevakumarJonathan C K Wells

Abstract

Background. Body composition is important as a marker of both current and future health. Bioelectrical impedance (BIA) is a simple and accurate method for estimating body composition, but requires population-specific calibration equations. Objectives. (1) To generate population specific calibration equations to predict lean mass (LM) from BIA in Nepalese children aged 7-9 years. (2) To explore methodological changes that may extend the range and improve accuracy. Methods. BIA measurements were obtained from 102 Nepalese children (52 girls) using the Tanita BC-418. Isotope dilution with deuterium oxide was used to measure total body water and to estimate LM. Prediction equations for estimating LM from BIA data were developed using linear regression, and estimates were compared with those obtained from the Tanita system. We assessed the effects of flexing the arms of children to extend the range of coverage towards lower weights. We also estimated potential error if the number of children included in the study was reduced. Findings. Prediction equations were generated, incorporating height, impedance index, weight and sex as predictors (R (2) 93%). The Tanita system tended to under-estimate LM, with a mean error of 2.2%, but exte...Continue Reading

References

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Citations

Feb 6, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·Jonathan C K WellsDavid Osrin
May 3, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·Akanksha A MarphatiaDavid Osrin
Feb 7, 2017·Isotopes in Environmental and Health Studies·Wendell Costa BilaAlexsandro Sobreira Galdino
Apr 28, 2017·Maternal & Child Nutrition·Delan DevakumarJonathan C K Wells
Oct 9, 2020·The British Journal of Nutrition·Gabriela SalazarCamila Corvalán
Aug 14, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jonathan Ck WellsMary S Fewtrell
Feb 22, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Desirée Gutiérrez-MarínVeronica Luque

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