Body composition is associated with clinical outcomes in patients with non-dialysis-dependent chronic kidney disease

Kidney International
Ting-Yun LinDer-Cherng Tarng

Abstract

An inverse relationship between body mass index (BMI) and mortality (the obesity paradox) has been found in patients with non-dialysis-dependent chronic kidney disease (CKD). However, it is unclear whether increased muscle mass or body fat confers the survival advantage. To resolve this we investigated the impact of body makeup on a composite outcome of death or cardiovascular events in a prospective cohort of 326 patients with stage 3-5 CKD not yet on dialysis. Lean mass and body fat were determined using the Body Composition Monitor, a multifrequency bioimpedance spectroscopy device, and were expressed as the lean tissue or fat tissue index, respectively. Patients were stratified as High (above median) or Low (below median) BMI, High or Low lean tissue index, or as High or Low fat tissue index. During a median follow-up of 4.6 years, there were 40 deaths and 68 cardiovascular events. In Cox proportional hazards models, a High lean tissue index, but not High BMI or High fat tissue index, predicted a lower risk of both the composite or its component outcomes (reference: below median). When patients were further stratified into four distinct body composition groups based on both the lean and fat tissue index, only the High lean/...Continue Reading

Citations

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Dec 12, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Young Youl HyunUNKNOWN KNOW-CKD Study Investigator
Oct 16, 2018·The American Journal of Clinical Nutrition·Ting-Yun LinSzu-Chun Hung
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May 18, 2021·Osteoporosis and Sarcopenia·Ching-Lung CheungChih-Hsing Wu

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