Body Composition Using Air Displacement Plethysmography in Children With Inflammatory Bowel Disease.

Journal of Pediatric Gastroenterology and Nutrition
Jasbir DhaliwalMarialena Mouzaki

Abstract

The aim of the study was to assess the body composition of children with inflammatory bowel disease (IBD) and to study the accuracy of clinically available tools in predicting excess body fatness. We aimed at also exploring the influence of adiposity on pharmacokinetics during early Infliximab exposure. Prospective cohort study in 5- to 17-year-old children with IBD initiating Infliximab therapy. Patient demographic, phenotypic, and laboratory data at the time of Infliximab initiation were recorded. Body composition was assessed using air displacement plethysmography (ADP). fat mass index (FMI = fat mass [kg]/(height [m])) was calculated to determine excess adiposity (defined as FMI ≥75th centile). Anthropometrics (weight, height, mid upper arm circumference [MUAC] and triceps skin fold thickness [TSF]) were obtained and MUAC and TSF measurements were used to calculate arm fat area (AFA) and arm muscle area z-scores. Statistical analysis was applied as appropriate. Fifty-three (68% male; 55% Crohn disease [CD], 45% ulcerative colitis [UC], median [IQR] age 15 [13-16] years) children with IBD were included. Twenty-four percentage of children with IBD (21% CD, 29% UC) had excess adiposity. Four children (31%) with FMI ≥75th centi...Continue Reading

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Citations

Jan 16, 2021·International Journal of Clinical Practice·Hadeel A AlsufyaniOmar I Saadah
Apr 14, 2021·Journal of Paediatrics and Child Health·Thea von GraffenriedAndreas Nydegger
Jun 7, 2021·Journal of Pediatric Gastroenterology and Nutrition·Francesca PenaginiGian Vincenzo Zuccotti

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