Body fat accumulation in zebrafish is induced by a diet rich in fat and reduced by supplementation with green tea extract

PloS One
Shinichi MeguroTadashi Hase

Abstract

Fat-rich diets not only induce obesity in humans but also make animals obese. Therefore, animals that accumulate body fat in response to a high-fat diet (especially rodents) are commonly used in obesity research. The effect of dietary fat on body fat accumulation is not fully understood in zebrafish, an excellent model of vertebrate lipid metabolism. Here, we explored the effects of dietary fat and green tea extract, which has anti-obesity properties, on body fat accumulation in zebrafish. Adult zebrafish were allocated to four diet groups and over 6 weeks were fed a high-fat diet containing basal diet plus two types of fat or a low-fat diet containing basal diet plus carbohydrate or protein. Another group of adult zebrafish was fed a high-fat diet with or without 5% green tea extract supplementation. Zebrafish fed the high-fat diets had nearly twice the body fat (visceral, subcutaneous, and total fat) volume and body fat volume ratio (body fat volume/body weight) of those fed low-fat diets. There were no differences in body fat accumulation between the two high-fat groups, nor were there any differences between the two low-fat groups. Adding green tea extract to the high-fat diet significantly suppressed body weight, body fat ...Continue Reading

References

Jan 1, 1992·Neuroscience and Biobehavioral Reviews·Z S Warwick, S S Schiffman
Jan 1, 1986·Annual Review of Biophysics and Biophysical Chemistry·G Wiegand, S J Remington
Sep 1, 1969·European Journal of Biochemistry·A BassD Pette
Nov 1, 1969·European Journal of Biochemistry·P Wunderwald, H Eggerer
Oct 1, 1984·AJR. American Journal of Roentgenology·H I GoldbergP F van Waes
Apr 1, 1984·The American Journal of Clinical Nutrition·W O GrauerH I Goldberg
Jan 1, 1983·The British Journal of Nutrition·F BourgeoisD Lemonnier
Sep 1, 1995·Obesity Research·Y MatsuzawaK Tokunaga
Dec 1, 1996·Metabolism: Clinical and Experimental·S IkemotoO Ezaki
Nov 11, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S BertraisE Eschwège
Feb 23, 2000·Journal of Nutritional Science and Vitaminology·M TakahashiO Ezaki
Mar 10, 2000·Advances in Experimental Medicine and Biology·S Y Yang, X Y He
Sep 26, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M Tschöp, M L Heiman
Nov 20, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T MuraseI Tokimitsu
Mar 27, 2004·Metabolism: Clinical and Experimental·Ann E PetroRichard S Surwit
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Oct 26, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T MuraseI Tokimitsu
Nov 16, 2005·Medicine and Science in Sports and Exercise·Akira ShimotoyodomeIchiro Tokimitsu
Jan 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takatoshi MuraseTadashi Hase
Jul 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Hidehiko KondoTakatoshi Murase
Mar 8, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Youngsup Song, Roger D Cone
Apr 12, 2007·Obesity·Roland BuettnerL Cornelius Bollheimer
Apr 19, 2007·Nature Reviews. Genetics·Graham J Lieschke, Peter D Currie
Nov 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arnaud DelormeScott Makeig
Apr 8, 2010·Disease Models & Mechanisms·Toshihiko MatsumotoIsao Sakaida
Jun 29, 2010·The Biochemical Journal·Maarit Hölttä-VuoriElina Ikonen
Oct 28, 2010·Nutrition Research Reviews·Niloofar Hariri, Louise Thibault
May 10, 2011·Methods in Cell Biology·Jennifer L AndersonSteven A Farber
May 27, 2011·Annals of Medicine·Ken KishidaIichiro Shimomura

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Citations

Mar 9, 2018·The Journal of Experimental Biology·Cristina Salmerón
Dec 24, 2017·Endocrine·Marta CarnovaliMassimo Mariotti
Dec 1, 2017·Zebrafish·Shinichi Meguro, Takahiro Hasumura
Mar 30, 2017·Disease Models & Mechanisms·James E N Minchin, John F Rawls
Nov 1, 2018·Revista do Colégio Brasileiro de Cirurgiões·Taíse FuchsThaís Andrade Costa-Casagrande
Jul 19, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Navrinder KaurRamesh Chandra
Aug 27, 2017·Fish Physiology and Biochemistry·Rafael Vargas, Isabel Cristina Vásquez
May 24, 2019·Experimental Animals·Khaled BenchoulaHesham R El-Seedi
Jan 1, 2020·Genes & Nutrition·Michael B Williams, Stephen A Watts
Mar 21, 2019·Animal Models and Experimental Medicine·Francesca FaillaciErica Villa
Nov 21, 2019·Scientific Reports·Shinichi MeguroTakahiro Hasumura
Mar 7, 2020·Advances in Nutrition·Winyoo ChowanadisaiMark A Messerli
Sep 5, 2018·Frontiers in Cell and Developmental Biology·Liqing ZangWenbiao Chen
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiroko NakayamaYasuhito Shimada
Jan 6, 2021·Animals : an Open Access Journal From MDPI·Maryna van de VenterLuanne Venables
Feb 25, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Victor L PicoloDenis B Rosemberg
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe MontalbanoAntonino Germanà
Mar 13, 2021·Eating and Weight Disorders : EWD·Medine TürkoğluSaltuk Buğrahan Ceyhun
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe MontalbanoAntonino Germanà

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