PMID: 8968856Dec 1, 1996Paper

Body fat accumulation is possibly responsible for lower dehydroepiandrosterone circulating levels in premenopausal obese women

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
G De PergolaR Giorgino

Abstract

To determine whether any androgen is independently related with parameters of body fat accumulation and distribution in obese women. Circulating insulin and androgen levels (total testosterone (T), free testosterone (FT), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione, sex hormone binding globulin (SHBG)) and the parameters of body fat accumulation and distribution (body mass index, waist-to-hip ratio, total body fat volume (TBF), visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) were determined in a population of non-diabetic obese women. 28 premenopausal obese women, recruited at the Verona University Hospital Outpatient Clinic. TBF, VAT and SAT area were quantified by computed tomography. Hormone levels were measured by RIA. SHBG showed an inverse correlation with BMI (r: -0.452, P < 0.05), WHR (r: -0.388, P < 0.05), TBF (r: -0.509, P < 0.01), VAT (r: -0.378, P < 0.05) and SAT (r: -0.449, P < 0.05). DHEA was negatively associated with BMI (r: -0.376, P < 0.05), TBF (r: -0 < 0.05), VAT (r: -0.662, P < 0.001) and SAT (r: -0.401, p < 0.05). T was found to be inversely related with VAT (r: -0.401, P < 0.05). Androstenedione was positively correlated with WHR (r:...Continue Reading

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