PMID: 11915581Mar 28, 2002Paper

Body fat distribution, insulin sensitivity, ovarian dysfunction and serum lipoproteins in patients with polycystic ovary syndrome

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
T StrowitzkiT Demant

Abstract

Polycystic ovary syndrome (PCOS) is characterized by various endocrine and metabolic abnormalities, whose mutual associations and symptoms are still not clear. In the present study, fifteen PCOS patients and fifteen controls, matched for age and body weight, were investigated. Endocrine profiles were evaluated by the nafarelin and the adrenocorticotropin (ACTH) test. Insulin sensitivity was determined by an intravenous insulin tolerance test. Patients showed a significant predominance of abdominal adiposity [waist-to-hip ratio (WHR), 0.86 +/- 0.05 vs. 0.79 +/- 0.04] with markedly higher fasting insulin levels (+75%) and reduced insulin sensitivity (-37%). Fasting insulin, testosterone and free androgen index were positively correlated with the body mass index (BMI). In contrast, insulin sensitivity and BMI were inversely correlated in patients only. In the nafarelin test increases of 17-OH-progesterone and androstenedione were higher in patients and positively correlated with fasting insulin levels. Lipoprotein profiles showed trends towards higher triglycerides, lower HDL-cholesterol and a preponderance of small, dense LDL in patients. In PCOS higher triglycerides and lower HDL cholesterol were correlated with insulin sensitiv...Continue Reading

Citations

Aug 24, 2005·The British Journal of Nutrition·Kate Marsh, Jennie Brand-Miller
Mar 6, 2007·Fertility and Sterility·Te-Fu ChanEing-Mei Tsai
Nov 2, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S S LimL J Moran
May 10, 2006·Journal of Endocrinological Investigation·P A Essah, J E Nestler

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