Body-Integrated, Enzyme-Triggered Degradable, Silk-Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment

Advanced Science
Shan ZhangTiger H Tao

Abstract

Mechanical signals such as pressure and strain reflect important psychological and physiological states of the human body. Body-integrated sensors, including skin-mounted and surgically implanted ones, allow personalized health monitoring for the general population as well as patients. However, the development of such measuring devices has been hindered by the strict requirements for human-biocompatible materials and the need for high performance sensors; most existing devices or sensors do not meet all the desired specifications. Here, a set of flexible, stretchable, wearable, implantable, and degradable mechanical sensors is reported with excellent mechanical robustness and compliance, outstanding biocompatibility, remotely-triggered degradation, and excellent sensing performance, using a conductive silk fibroin hydrogel (CSFH). They can detect multiple mechanical signals such as pressure, strain, and bending angles. Moreover, combined with a drug-loaded silk-based microneedle array, sensor-equipped devices are shown to be effective for real-time monitoring and in situ treatment of epilepsy in a rodent model. These sensors offer potential applications in custom health monitoring wearables, and in situ treatment of chronic cli...Continue Reading

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Citations

Apr 17, 2021·International Journal of Pharmaceutics·Ruxuan WangJianqing Gao
Jul 27, 2021·Advanced Science·Jungyoon OhnHyungil Jung
Nov 4, 2020·ACS Applied Materials & Interfaces·Qi ZhangJingye Pan

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