Abstract
In chronic kidney disease (CKD), a higher body mass index (BMI) is associated with a lower risk for death, but cause-specific death details are unknown across the BMI range. To define this, we studied 54,506 patients with CKD (stage 3 CKD- [91.5%]) from an institutional electronic medical record based-registry. We examined the associations among various causes of death (cardiovascular-, malignancy- and noncardiovascular/nonmalignancy-related deaths) across the BMI range using Cox proportional hazards and competing risks regression models. During a median follow-up of 3.7 years, 14,518 patients died. In the multivariable model, an inverted J-shaped association was noted between BMI and cardiovascular-related, malignancy-related, and noncardiovascular/nonmalignancy-related deaths. Similar associations were noted for BMI 25-29.9, 30-34.9, and 35-39.9 kg/m(2) categories. A BMI >40 kg/m(2) was not associated with cardiovascular-related and noncardiovascular/nonmalignancy-related deaths in CKD. Sensitivity analyses yielded similar results even after adjusting for proteinuria and excluding diabetes and hypertension from the models. In CKD, compared with a BMI of 18.5-24.9 kg/m(2), those who are overweight, with class 1 and 2 obesity h...Continue Reading
References
Apr 25, 2003·The New England Journal of Medicine·Eugenia E CalleMichael J Thun
May 18, 2004·Seminars in Dialysis·Srinivasan Beddhu
Jan 4, 2006·Annals of Internal Medicine·Chi-yuan HsuAlan S Go
May 4, 2006·Annals of Internal Medicine·Micah L Thorp
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Marcello TonelliAmit X Garg
May 3, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Csaba P KovesdyKamyar Kalantar-Zadeh
Aug 24, 2007·The New England Journal of Medicine·Ted D AdamsSteven C Hunt
Oct 12, 2007·Kidney International·Y WangL J Cheskin
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Katherine M FlegalMitchell H Gail
Sep 17, 2008·Annals of Internal Medicine·Todd A LeeKevin B Weiss
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jan 15, 2010·JAMA : the Journal of the American Medical Association·Katherine M FlegalLester R Curtin
May 21, 2010·Lancet·UNKNOWN Chronic Kidney Disease Prognosis ConsortiumRon T Gansevoort
Sep 30, 2010·Hypertension·Rajiv AgarwalRobert P Light
Nov 6, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Sankar D NavaneethanJoseph V Nally
May 24, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Holly KramerWilliam McClellan
Aug 9, 2012·JAMA : the Journal of the American Medical Association·Mercedes R CarnethonAlan R Dyer
Feb 16, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Sankar D NavaneethanJoseph V Nally
Mar 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Srinivasan Beddhu, Jo Abraham
Oct 1, 2013·Obesity·Deirdre K Tobias, Frank B Hu
Nov 2, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Lynae J HanksUNKNOWN REGARDS Investigators
Jan 17, 2014·The New England Journal of Medicine·Deirdre K TobiasFrank B Hu
Mar 22, 2014·Journal of the American Society of Nephrology : JASN·Jun Ling LuCsaba P Kovesdy
Apr 17, 2014·Obesity·Whitney R RobinsonHailey R Banack
Jun 20, 2014·Mayo Clinic Proceedings·Peter KokkinosJohn Peter Kokkinos
Jul 10, 2014·BMC Nephrology·Sankar D NavaneethanJesse D Schold
Nov 8, 2014·Circulation·Wenhui ZhaoGang Hu
Nov 14, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Juan Jesús Carrero
Nov 14, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Deep SharmaMatthew K Abramowitz
Dec 4, 2014·Stroke; a Journal of Cerebral Circulation·Weiqin LiGang Hu
Mar 4, 2015·Journal of the American Society of Nephrology : JASN·Stephanie ThompsonUNKNOWN Alberta Kidney Disease Network
Citations
May 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Haiquan HuangSankar D Navaneethan
Nov 12, 2016·The American Journal of Emergency Medicine·Yong Hun JungKyung Woon Jeung
Oct 19, 2017·Current Opinion in Nephrology and Hypertension·Carl P WaltherSankar D Navaneethan
Dec 7, 2017·PloS One·Craig H WardenJudith S Stern
Aug 17, 2018·International Journal of Nephrology·L Y WongM P H S Toh
Jul 2, 2020·BMC Nephrology·Tae YamamotoSadayoshi Ito
Jul 7, 2017·Journal of Medical Biochemistry·Velibor ČabarkapaVeljko Petrović
Dec 31, 2018·BMC Nephrology·Changwei WuLi Wang
Aug 24, 2019·BMC Nephrology·Zaimin WangWendy E Hoy
Aug 24, 2017·BJU International·Jitao WuSteven C Campbell
Dec 12, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Young Youl HyunUNKNOWN KNOW-CKD Study Investigator
Nov 17, 2019·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Wilfred DrumlPhilipp Metnitz
Jul 8, 2018·Progress in Cardiovascular Diseases·Neda NaderiHamid Moradi
Apr 28, 2018·Journal of Clinical Lipidology·Sankar D NavaneethanJoseph V Nally
Apr 4, 2021·Nutrients·Yasuyuki Nagasawa
May 28, 2021·Current Opinion in Nephrology and Hypertension·Vishnu P ParvathareddySankar D Navaneethan
Jul 29, 2017·Kidney International·Sankar D NavaneethanJoseph V Nally
Dec 24, 2021·Frontiers in Cardiovascular Medicine·Shin Yeong KangHyeon Seok Hwang
Dec 4, 2021·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Melissa SoohooOnyebuchi A Arah