Body mass index and causes of death in chronic kidney disease

Kidney International
Sankar D NavaneethanJoseph V Nally

Abstract

In chronic kidney disease (CKD), a higher body mass index (BMI) is associated with a lower risk for death, but cause-specific death details are unknown across the BMI range. To define this, we studied 54,506 patients with CKD (stage 3 CKD- [91.5%]) from an institutional electronic medical record based-registry. We examined the associations among various causes of death (cardiovascular-, malignancy- and noncardiovascular/nonmalignancy-related deaths) across the BMI range using Cox proportional hazards and competing risks regression models. During a median follow-up of 3.7 years, 14,518 patients died. In the multivariable model, an inverted J-shaped association was noted between BMI and cardiovascular-related, malignancy-related, and noncardiovascular/nonmalignancy-related deaths. Similar associations were noted for BMI 25-29.9, 30-34.9, and 35-39.9 kg/m(2) categories. A BMI >40 kg/m(2) was not associated with cardiovascular-related and noncardiovascular/nonmalignancy-related deaths in CKD. Sensitivity analyses yielded similar results even after adjusting for proteinuria and excluding diabetes and hypertension from the models. In CKD, compared with a BMI of 18.5-24.9 kg/m(2), those who are overweight, with class 1 and 2 obesity h...Continue Reading

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Citations

May 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Haiquan HuangSankar D Navaneethan
Nov 12, 2016·The American Journal of Emergency Medicine·Yong Hun JungKyung Woon Jeung
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Apr 28, 2018·Journal of Clinical Lipidology·Sankar D NavaneethanJoseph V Nally
May 28, 2021·Current Opinion in Nephrology and Hypertension·Vishnu P ParvathareddySankar D Navaneethan
Dec 24, 2021·Frontiers in Cardiovascular Medicine·Shin Yeong KangHyeon Seok Hwang
Dec 4, 2021·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Melissa SoohooOnyebuchi A Arah

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