Body mass index and chronic airflow limitation in a worldwide population-based study

Chronic Respiratory Disease
Lowie Egw VanfleterenFrits Me Franssen

Abstract

Nutritional status has been associated with clinical outcome in chronic airflow limitation (CAL), but epidemiological studies are scarce. We aimed to assess the relationship between body mass index (BMI) and CAL, taking into account confounding factors. 18,606 participants (49% male, 21% smokers, mean age: 55.8 ± 11.2 years, mean BMI: 26.7 ± 5.5 kg/m(2)) of the BOLD initiative from 26 sites in 23 countries were included. CAL was defined as post-bronchodilator forced expiratory volume in the first second/forced vital capacity < lower limit of normal. Low and obese BMI were defined as <21 kg/m(2) and ≥30 kg/m(2), respectively. Multivariate logistic regression analysis controlled for confounders age, sex and smoking, and meta-analysis of between-site heterogeneity and clustering. Prevalence of low and obese BMI, smoking history and prevalence of CAL were highly variable between sites. After adjustment for confounders, the meta-analysis of all sites showed that compared to subjects without CAL, low BMI was more frequent, (adjusted odds ratio (OR): 2.23 (95% confidence interval: 1.75, 2.85)) and conversely, obesity was less frequent in subjects with CAL (adjusted OR: 0.78 (0.65, 0.94)). In a worldwide population sample, CAL was asso...Continue Reading

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Citations

Jul 22, 2016·American Journal of Respiratory and Critical Care Medicine·Frits M E FranssenJohn R Cockcroft
Nov 10, 2017·Chronic Respiratory Disease·Benjamin D JamesRachael A Evans
Nov 22, 2017·Annals of the American Thoracic Society·Emiel F M Wouters
May 28, 2019·COPD·Filip J J TriestLowie E G W Vanfleteren
Jul 18, 2019·São Paulo Medical Journal = Revista Paulista De Medicina·Paulo Andrade Lotufo
Sep 5, 2019·São Paulo Medical Journal = Revista Paulista De Medicina·Paulo Andrade Lotufo
Apr 11, 2020·PloS One·Damien ViglinoUNKNOWN CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network
Dec 3, 2016·Current Opinion in Pulmonary Medicine·Corrine Hanson, Tricia LeVan
Mar 27, 2021·Respiratory Research·Felipe V C MachadoFrits M E Franssen
Nov 11, 2020·American Journal of Respiratory and Critical Care Medicine·Peter BurneyA Sonia Buist

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