Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies

BMC Cancer
Harinakshi SanikiniIsabelle Stücker

Abstract

Obesity has been proposed as a potential protective factor against lung cancer. We examined the association between BMI and lung cancer risk in a pooled analysis based on nested case-control studies from four cohort studies. A case-control study was nested within four cohorts in USA, Europe, China and Singapore that included 4172 cases and 8471 control subjects. BMI at baseline was calculated as weight in kilograms divided by height in meters squared (kg/m2), and classified into 4 categories: underweight (BMI < 18.5), normal weight (18.5 ≤ BMI < 25), overweight (25 ≤ BMI < 30) and obese (≥30). Odds ratios (ORs) and 95% confidence intervals (CIs) for BMI-lung cancer associations were estimated using unconditional logistic regression, adjusting for potential confounders. Considering all participants, and using normal weight as the reference group, a decreased risk of lung cancer was observed for those who were overweight (OR 0.77, 95% CI: 0.68-0.86) and obese (OR 0.69, 95% CI: 0.59-0.82). In the stratified analysis by smoking status, the decreased risk for lung cancer was observed among current, former and never smokers (P for interaction 0.002). The adjusted ORs for overweight and obese groups were 0.79 (95% CI: 0.68-0.92) and 0...Continue Reading

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Citations

Nov 23, 2019·European Journal of Epidemiology·Su-Min JeongEdward L Giovannucci
Sep 12, 2020·International Journal of Cancer. Journal International Du Cancer·Wen ZhouChristopher I Amos
Dec 19, 2019·Biological Trace Element Research·Muhammad Abdul QayyumDursun Kisa
Jan 17, 2021·Cancers·Sheetal ParidaDipali Sharma
Nov 28, 2020·Frontiers in Oncology·F H ArdeschJ C Kiefte-de Jong
Mar 16, 2021·Science Progress·Waleed AlbakerMohammed Al-Hariri
May 7, 2021·Cancer Treatment and Research Communications·Alvaro L RoncoWilson Golomar

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