Body mass index and mortality in lung cancer patients: a systematic review and meta-analysis

European Journal of Clinical Nutrition
J WangS Zhong

Abstract

Studies examining the relation of body mass index (BMI) and mortality in patients with lung cancer have shown diverse results. We conducted a meta-analysis to investigate the association using all available studies from January 1982 to October 2016. PubMed and EMBASE were searched to identify relevant studies. We calculated the summary hazard ratio (HR) and 95% confidence interval (CI) using random effects model. The dose-response relationship was assessed by random effects meta-regression model. Fifty-five articles from 51 studies involving 3 152 552 subjects (males, 54.8%) were included. The pooled results suggested that on average a high BMI decreased risk of death from lung cancer or all-cause. Each 5 kg/m2 increase in BMI had a 12% lower risk of lung cancer-specific mortality (HR=0.88, 95% CI: 0.75-1.02, P=0.09) and a 14% lower risk of all-cause mortality (HR=0.86, 95% CI: 0.77-0.96, P<0.01). When stratifying by ethnicity, each 5 kg/m2 increase in BMI was associated with 22% and 28% reduction, respectively, in the risk of lung cancer-specific mortality (P<0.01) and all-cause mortality (P<0.01) in Asians, but no association was found in Westerners (P=0.51 and P=0.53, respectively). In conclusion, lung cancer patients with a...Continue Reading

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Citations

Jul 18, 2019·Current Opinion in Supportive and Palliative Care·Iain PhillipsVeni Ezhil
Nov 26, 2020·British Journal of Cancer·Annie S AndersonUNKNOWN UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)
Nov 28, 2020·Frontiers in Oncology·F H ArdeschJ C Kiefte-de Jong
Apr 11, 2021·Bulletin du cancer·Raphaëlle AncellinPaule Latino-Martel
Dec 12, 2020·Clinical Lung Cancer·Maria Cristina MeleEmilio Bria
Apr 14, 2020·Revue des maladies respiratoires·T PierretA Toffart

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