Body Mass Index and Mortality Rate in Korean Patients with Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Hyemin JangSang Won Seo

Abstract

A relationship between body weight, cognitive impairment, and the onset of Alzheimer's disease (AD) was recently reported. However, to our knowledge, no studies have investigated the relationship between body weight and mortality in Asian AD patients. We evaluated the relationship between body mass index (BMI) and mortality rate in Korean AD cohorts. Participants were consecutively included from two Korean representative registries: 579 AD patients from Samsung Medical Center and 1911 AD patients from the Clinical Research Center for Dementia of South Korea study. We combined these two AD cohorts to evaluate the association between BMI and mortality. BMI was used to categorize the participants into underweight, normal-weight, overweight, and obesity subgroups. All deaths were confirmed through the nationwide mortality database of Statistics Korea. 53 of 181 (29.3%), 208 of 1,127 (18.5%), 88 of 626 (14.1%), and 115 of 556 (20.7%) patients died in the underweight, normal-weight, overweight, and obese subgroups during 43.7 months of follow-up. The time-dependent cox proportional hazards model showed that, relative to the normal-weight subgroup, the underweight group had higher mortality (HR 1.82 (95% CI, 1.07-3.09)) while overweig...Continue Reading

References

Mar 1, 1996·Journal of the American Geriatrics Society·H WhiteG Fillenbaum
May 19, 1998·Nutrition Reviews·B M Popkin, C M Doak
Apr 15, 2000·Nature·P G Kopelman
Aug 31, 2001·Journal of the American College of Cardiology·T B HorwichJ H Tillisch
Nov 27, 2002·Journal of Affective Disorders·Pim Cuijpers, Filip Smit
Dec 11, 2002·Journal of the American Geriatrics Society·Margareta D PerssonTommy E Cederholm
Jul 2, 2003·Journal of the American Geriatrics Society·Heather H KellerHeather M Brown
Oct 14, 2003·Journal of Applied Physiology·Fulvio LauretaniLuigi Ferrucci
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Scott M Grundy
Feb 8, 2005·The American Journal of Cardiology·Luis GrubergUNKNOWN Arterial Revascularization Therapies Study Investigators
May 3, 2005·BMJ : British Medical Journal·Rachel A WhitmerKristine Yaffe
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Aug 24, 2006·The New England Journal of Medicine·Sun Ha JeeJonathan M Samet
Jan 24, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Darren Schmidt, Abdulla Salahudeen
Oct 2, 2007·The American Journal of Medicine·Seth UretskyCarl J Pepine
Mar 1, 2008·Neuroepidemiology·Tom Skyhøj OlsenKlaus Kaae Andersen
Jun 6, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Marc NoconStefan N Willich
Jul 22, 2008·Chest·Wael GalalDon Poldermans
Feb 18, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sang Won SeoDuk L Na
Mar 11, 2009·Archives of Neurology·Annette L FitzpatrickJosé A Luchsinger
Jul 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ron BrookmeyerH Michael Arrighi
Mar 17, 2010·Intensive Care Medicine·Wilfred DrumlPhilipp G H Metnitz
Apr 14, 2010·Archives of Neurology·Jeffrey M BurnsWilliam M Brooks
Feb 25, 2011·The New England Journal of Medicine·Wei ZhengJohn D Potter
Feb 26, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K J AnsteyJ Young
Nov 10, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Seong Hye ChoiKyung Won Park
Aug 17, 2012·Neurology·Beom Joon KimUNKNOWN For Korean Stroke Registry investigators
Sep 6, 2012·Circulation·Jean-Pierre Després
Jan 3, 2013·JAMA : the Journal of the American Medical Association·Katherine M FlegalBarry I Graubard
Aug 27, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Matthew F Bouchonville, Dennis T Villareal
Apr 12, 2014·Journal of the American Medical Directors Association·Sara García-PtacekMaria Eriksdotter

❮ Previous
Next ❯

Citations

Dec 4, 2019·Aging·Ling-Zhi MaAlzheimer's Disease Neuroimaging Initiative
Feb 26, 2019·The Journal of Clinical Endocrinology and Metabolism·Ji-Yeon LeeYong-Ho Lee
Aug 15, 2020·Frontiers in Psychiatry·Yvonne EisenmannKlaus Maria Perrar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.