Body mass index and response to tocilizumab in rheumatoid arthritis: a real life study

Clinical Rheumatology
Anais GardettePhilippe Dieudé

Abstract

Several studies have suggested that obesity could have a negative effect on response to anti-tumor necrosis factor α (anti-TNFα) in rheumatoid arthritis (RA). Little is known about the impact of body mass index (BMI) on other biologic agents. We aimed to evaluate the effect of BMI on response to tocilizumab (TCZ) in RA. RA patients treated with TCZ were included in this multicenter retrospective study. BMI was calculated at the initiation of treatment. After 6 months of treatment, change from baseline in DAS28, pain on a visual analog scale, erythrocyte sedimentation rate and C-reactive protein level, and tender and swollen joints were analyzed. The primary endpoint was decrease in DAS28 ≥ 1.2. Secondary outcomes were good response and remission by EULAR criteria. At baseline, among 115 RA patients included, the median (interquartile range) BMI was 25.4 (22.0-28.8) kg/m(2). The number of patients with normal weight, overweight, and obesity was 53 (46 %), 37 (32 %), and 25 (22 %), respectively. Baseline characteristics did not differ between the three subgroups of BMI. The median BMI did not differ between responders and non-responders for DAS28 decrease ≥1.2 (25.7 [22.1-29.9] vs 24.9 [22.0-27.1], P = 0.38), EULAR good response ...Continue Reading

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Citations

Oct 14, 2016·European Journal of Clinical Investigation·Anais GardettePhilippe Dieudé
Mar 3, 2018·Immunotherapy·Raimon SanmartíDolor Soy
May 16, 2019·Expert Opinion on Drug Delivery·Atsushi OgataKeiji Maeda
Jun 2, 2020·European Journal of Clinical Investigation·Shmuel TiosanoHoward Amital
Feb 6, 2020·Clinical Rheumatology·Luca MoroniLorenzo Dagna
Aug 20, 2017·Clinical Rheumatology·Maria-Antonietta D'AgostinoGianfranco Ferraccioli
Mar 29, 2021·Zeitschrift für Rheumatologie·Ulf Müller-LadnerAndreas Schäffler
Jul 25, 2021·Journal of Clinical Medicine·Enriqueta Vallejo-YagüeAndrea M Burden
Aug 17, 2021·Frontiers in Immunology·Giada MondanelliCiriana Orabona
Nov 6, 2021·Arthritis Research & Therapy·Sook Yan LeeDavid L Scott

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