Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study.

PLoS Medicine
Tormod RogneJan Kristian Damås

Abstract

In observational studies of the general population, higher body mass index (BMI) has been associated with increased incidence of and mortality from bloodstream infection (BSI) and sepsis. On the other hand, higher BMI has been observed to be apparently protective among patients with infection and sepsis. We aimed to evaluate the causal association of BMI with risk of and mortality from BSI. We used a population-based cohort in Norway followed from 1995 to 2017 (the Trøndelag Health Study [HUNT]), and carried out linear and nonlinear Mendelian randomization analyses. Among 55,908 participants, the mean age at enrollment was 48.3 years, 26,324 (47.1%) were men, and mean BMI was 26.3 kg/m2. During a median 21 years of follow-up, 2,547 (4.6%) participants experienced a BSI, and 451 (0.8%) died from BSI. Compared with a genetically predicted BMI of 25 kg/m2, a genetically predicted BMI of 30 kg/m2 was associated with a hazard ratio for BSI incidence of 1.78 (95% CI: 1.40 to 2.27; p < 0.001) and for BSI mortality of 2.56 (95% CI: 1.31 to 4.99; p = 0.006) in the general population, and a hazard ratio for BSI mortality of 2.34 (95% CI: 1.11 to 4.94; p = 0.025) in an inverse-probability-weighted analysis of patients with BSI. Limitation...Continue Reading

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Citations

Aug 21, 2021·Pharmacogenomics and Personalized Medicine·Shujuan ChuYue Qian
Oct 31, 2021·Journal of Hepato-biliary-pancreatic Sciences·Yusuke HanabataJun Tamura

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Methods Mentioned

BETA
genotyping

Software Mentioned

Hmisc
R
ipw
HUNT
ggplot2
Stata
PLINK
gtools
lm
metafor

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