Body Mass Index and Sex Affect Diverse Microbial Niches within the Gut

Frontiers in Microbiology
Francesca BorgoElisa Borghi

Abstract

Gut microbiota is considered a separate organ with endocrine capabilities, actively contributing to tissue homeostasis. It consists of at least two separate microbial populations, the lumen-associated (LAM) and the mucosa-associated microbiota (MAM). In the present study, we compared LAM and MAM, by collecting stools and sigmoid brush samples of forty adults without large-bowel symptoms, and through a 16S rRNA gene next-generation sequencing (NGS) approach. MAM sample analysis revealed enrichment in aerotolerantProteobacteria, probably selected by a gradient of oxygen that decreases from tissue to lumen, and inStreptococcusandClostridiumspp., highly fermenting bacteria. On the other hand, LAM microbiota showed an increased abundance inBacteroides, Prevotella, andOscillospira, genera able to digest and to degrade biopolymers in the large intestine. Predicted metagenomic analysis showed LAM to be enriched in genes encoding enzymes mostly involved in energy extraction from carbohydrates and lipids, whereas MAM in amino acid and vitamin metabolism. Moreover, LAM and MAM communities seemed to be influenced by different host factors, such as diet and sex. LAM is affected by body mass index (BMI) status. Indeed, BMI negatively correla...Continue Reading

References

Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
May 12, 2001·The British Journal of Nutrition·R J Hill, P S Davies
Jul 24, 2004·Microbiology and Immunology·Arthur C OuwehandErika Isolauri
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Dec 8, 2005·Applied and Environmental Microbiology·Catherine Lozupone, Rob Knight
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Feb 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Min LiLiping Zhao
Apr 15, 2009·Gerontology·Maximilian Zeyda, Thomas M Stulnig
Jun 6, 2009·The Journal of Physiology·Peter J Turnbaugh, Jeffrey I Gordon
Aug 21, 2009·Digestive Diseases and Sciences·Caroline CodlingJulian R Marchesi
Feb 4, 2010·Ecology·Miquel De Cáceres, Pierre Legendre
Aug 17, 2010·Bioinformatics·Robert C Edgar
Mar 3, 2011·FEMS Microbiology Reviews·Pieter Van den AbbeeleSam Possemiers
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Jul 9, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ian M CarrollYehuda Ringel
Jul 13, 2011·Frontiers in Microbiology·François ThomasGurvan Michel
Nov 8, 2011·Journal of Proteome Research·Renaud MestdaghJeremy K Nicholson
Feb 16, 2012·BMC Bioinformatics·Andre P MasellaJosh D Neufeld
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Jul 27, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Intan H IsmailMimi L K Tang
Sep 5, 2012·Nature Reviews. Gastroenterology & Hepatology·Harry J FlintSylvia H Duncan
Aug 27, 2013·Nature Biotechnology·Morgan G I LangilleCurtis Huttenhower
Jan 25, 2014·Current Opinion in Gastroenterology·Erwin G Zoetendal, Willem M de Vos
May 17, 2014·Gut·Herbert Tilg, Alexander R Moschen
Jun 4, 2014·Molecular Endocrinology·Gerard ClarkeTimothy G Dinan
Jun 25, 2014·Trends in Molecular Medicine·Yuliya E BorreJohn F Cryan
Aug 2, 2014·World Journal of Gastroenterology : WJG·Kang Nyeong Lee, Oh Young Lee
Oct 14, 2014·Journal of Immunology Research·Caroline Marcantonio FerreiraFlaviano dos Santos Martins
Dec 17, 2014·The British Journal of Nutrition·Zhenjiang Xu, Rob Knight
Dec 21, 2014·Gut·Jonna JalankaWillem M de Vos
Apr 16, 2015·PloS One·Christine DominianniJiyoung Ahn
Sep 5, 2015·Gut·Julian R MarchesiAilsa Hart
Oct 27, 2015·Nature Reviews. Microbiology·Gregory P DonaldsonSarkis K Mazmanian
Mar 22, 2016·Trends in Microbiology·Tom Konikoff, Uri Gophna
May 27, 2016·PloS One·Carmen HaroAntonio Camargo
Jun 30, 2016·Gut Microbes·Elin OrgAldons J Lusis

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Citations

Jan 27, 2019·Scientific Reports·Kimberly A Dill-McFarlandPamela Herd
Jun 19, 2020·Nutrients·Noemí Redondo-UserosAscensión Marcos
Jul 11, 2018·Frontiers in Microbiology·Xuefeng GaoYi Hao
Dec 24, 2018·Nutrients·Dolores CorellaJose M Ordovas
Apr 17, 2019·Journal of Clinical Medicine·Negar NaderpoorBarbora de Courten
Sep 21, 2020·Journal of Endocrinological Investigation·F BorgoR C Melcangi
Apr 1, 2019·The World Journal of Men's Health·Yong Sung KimMi Sung Park
Jan 29, 2020·Molecular Ecology Resources·Jia ZhouLee Ann Rollins
Aug 19, 2020·Molecular Biology Reports·Ayane MikamiTakeshi Shimosato
Jul 25, 2019·Frontiers in Immunology·Na LiJin-Lian Hua
Jul 30, 2020·Microbial Cell Factories·Xin YuanXiaohong Yang
Jun 25, 2019·Microbes and Infection·Galina Novik, Victoria Savich
Jan 23, 2021·Journal of Equine Veterinary Science·Dini HuKai Li
Jun 5, 2020·Frontiers in Neuroendocrinology·Christina L HayesJane A Foster
May 2, 2021·BMC Microbiology·Alexander KoliadaAlexander Vaiserman
May 28, 2021·World Journal of Gastroenterology : WJG·Xia LiuZong-Xin Ling
Oct 8, 2021·Scientific Reports·Jarrett D MorrowCraig P Hersh
Oct 26, 2021·Frontiers in Cellular and Infection Microbiology·Jiaxing TianXiaolin Tong

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Datasets Mentioned

BETA
PRJNA401981

Methods Mentioned

BETA
PCR
biopsy

Software Mentioned

PAired
R
BLAST
- eND Assembler for
indicspecies
vegan
UCLUST
QIIME
PICRUSt
PandaSeq

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