Body mass index determines the response of plasma sulfur amino acids to methionine loading.

Biochimie
Amany K ElshorbagyHelga Refsum

Abstract

Evidence from human, animal and cellular studies suggests that high plasma total cysteine (tCys) is causally linked to human obesity, but determinants of population tCys variability are unknown. We hypothesized that tCys elevation in obesity may be mediated by an altered tCys response to intake of its precursor, methionine. We investigated whether BMI influences the change in plasma tCys, total homocysteine (tHcy) and total cysteinylglycine (tCysGly) 6h following a 100 mg/kg oral methionine load in 800 healthy subjects and 750 cardiovascular disease (CVD) cases. Methionine loading decreased tCys from mean 275 (95% CI, 273, 277) μmol/L to 253 (251,255) μmol/L. The decline in tCys was less in overweight (-8%) and obese (-6%) compared to normal weight (-9%) subjects, adjusting for age, gender and CVD (P-ANOVA = 0.006). Compared to normal weight subjects, individuals with obesity had a 2.8-fold likelihood (95% CI, 1.52, 5.01) of experiencing a rise (rather than decline), in tCys postload, after multiple adjustments. tCysGly also decreased postload, and the decline was similarly smaller in overweight (-18%) and obese (-15%) compared to normal weight (-21%) individuals (P-ANOVA <0.001). The tHcy response was modified by CVD status, w...Continue Reading

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Citations

Dec 23, 2020·Nutrition Reviews·Luana de Oliveira LeitePriscila Ribas de Farias Costa
Aug 15, 2021·The Lancet. Planetary Health·Cajetan Neubauer, Hannah Landecker

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