Body mass index is independently associated with xanthine oxidase activity in overweight/obese population

Eating and Weight Disorders : EWD
Aleksandra KlisicAna Ninic

Abstract

The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = - 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity pre...Continue Reading

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Sep 13, 2017·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Aleksandra KlisicAna Ninic

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Citations

Oct 15, 2020·International Journal of Molecular Sciences·You-Jin KimYong-Lim Kim
Mar 23, 2021·Frontiers in Cardiovascular Medicine·Yawen ZhouNing Xia
Apr 15, 2021·Nutrition & Diabetes·Takashi NakamuraHiroki Mizukami
May 4, 2021·Oxidative Medicine and Cellular Longevity·Aleksandra KlisicAna Ninic
Aug 13, 2021·Oxidative Medicine and Cellular Longevity·Petar VukicevicJelena Kotur-Stevuljevic
Sep 18, 2021·Scientific Reports·Aleksandra KlisicJelena Kotur-Stevuljevic

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