Abstract
Intensified insulin therapy may increase body weight and cause obesity. This study compared body mass index standard deviation score (BMISDS) and obesity rate in children with type 1 diabetes (T1D) in Denmark, Iceland, Norway and Sweden, and uncovered predictors for increasing BMISDS. Data registered in the Nordic national childhood diabetes databases during the period 2008-2012 on children below 15 years with T1D for more than 3 months were compiled, including information on gender, age, diabetes duration, hemoglobin A1c (HbA1c ), insulin dose, severe hypoglycemia (SH), treatment modality, height and weight. The Swedish reference chart for BMI was used for calculating BMISDS. Totally, 11 025 children (48% females) (30 994 registrations) were included. Medians by the last recorded examination were: age, 13.5 years; diabetes duration, 4.3 years; HbA1c , 7.9% (63 mmol/mol); insulin dose, 0.8 IU/kg/d and BMISDS, 0.70. Obesity rate was 18.5%. Adjusted mean BMISDS (BMISDS adj) was inversely related to HbA1c and directly to diabetes duration. Higher BMISDS adj was found in those with an insulin dose above 0.6 IU/kg/d, and in girls above 10 years. Pump users had higher BMISDS adj than pen users, and patients with registered SH had hig...Continue Reading
References
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Nov 1, 1995·Diabetes Care
Mar 1, 1997·Diabetes Care·T DanneB Weber
Jun 17, 1998·Diabetologia·R W HollK M Debatin
Jul 2, 1999·Diabetes Care·K V WilliamsT J Orchard
Nov 25, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·C-M IngbergJ Aman
May 1, 2007·Diabetes Care·Antje HerbstUNKNOWN DPV Initiative of the German Working Group for Pediatric Diabetology Germany
May 22, 2007·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·B-M Kurth, A Schaffrath Rosario
Dec 18, 2007·Pediatrics·Sarah E Barlow, UNKNOWN Expert Committee
Jan 18, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·B I JakischUNKNOWN German/Austrian DPV Initiative and Working Group for Paediatric Pump Therapy
Jan 19, 2008·Acta Paediatrica·Agneta SjöbergStaffan Mårild
May 29, 2009·Pediatric Diabetes·Lenna L LiuUNKNOWN SEARCH for Diabetes in Youth Study Group
Apr 21, 2010·Nature Reviews. Cardiology·Aparna BrownDennis Bruemmer
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·B ConwayT J Orchard
Sep 11, 2010·European Journal of Endocrinology·N H BirkebaekH Gronbaek
Jul 16, 2011·Journal of Pediatric Gastroenterology and Nutrition·Henning GrønbækHendrik Vilstrup
Dec 6, 2012·Circulation·Jonathan Q PurnellUNKNOWN DCCT/EDIC Research Group
Jan 24, 2013·Diabetes Research and Clinical Practice·T R NanselR J Iannotti
Jul 31, 2013·Pediatric Diabetes·Maria J RedondoUNKNOWN Pediatric Diabetes Consortium
Oct 24, 2013·Diabetologia·Torild SkrivarhaugUNKNOWN Norwegian Childhood Diabetes Study Group
Nov 8, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Thomas M KapellenUNKNOWN DPV-Science-Initiative of the German Competence Network Diabetes and the German Competence Network Obesity (Consortium LARGE
May 9, 2014·Archives of Disease in Childhood·Elke E Fröhlich-ReitererUNKNOWN DPV-Wiss Study Group and German BMBF Competence Networks Diabetes mellitus and Obesity
May 31, 2014·Journal of Diabetes Science and Technology·Lena HanbergerUlf Samuelsson
Jul 22, 2014·Pediatric Diabetes·Charumathi BaskaranLori M Laffel
Jul 22, 2014·Pediatric Diabetes·Trang T LyTimothy W Jones
Aug 30, 2014·Circulation·David M MaahsUNKNOWN American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Dis
Nov 26, 2014·BMC Public Health·Lena HohwüCarsten Obel
Jun 17, 2015·Acta Diabetologica·Maria J RedondoLinda A DiMeglio
Jul 1, 2015·Journal of Diabetes Research·M Flechtner-MorsR W Holl
Jul 15, 2015·The Journal of Pediatrics·Stephanie N DuBoseUNKNOWN Type 1 Diabetes Exchange Clinic Network and Diabetes Prospective Follow-up Registry
Jul 27, 2015·Pediatric Clinics of North America·Muskaan GurnaniJill Hamilton
Jun 11, 2016·The Journal of Clinical Endocrinology and Metabolism·Thomas ReinehrReinhard W Holl
Jul 16, 2016·Pediatric Obesity·L M LipskyT R Nansel
Jul 18, 2016·Lancet· Global BMI Mortality CollaborationFrank Hu
Nov 25, 2016·Adolescent Health, Medicine and Therapeutics·Jean RankinJulien S Baker
Aug 2, 2017·BMJ Open Diabetes Research & Care·N H BirkebaekJ Svensson
Citations
Jul 29, 2019·Diabetes/metabolism Research and Reviews·Patrizia CalellaGiuliana Valerio
Jan 24, 2020·Pediatric Diabetes·Jens Otto Broby MadsenJesper Johannesen
Feb 23, 2020·Indian Journal of Pediatrics·Pragya ManglaPranjul Asthana
Nov 9, 2019·Pediatric Diabetes·Ulf SamuelssonUNKNOWN Nordic Childhood Diabetes Registry Study Group, NordicDiabKids
Sep 13, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·E H IbfeltJ Svensson
Jan 7, 2021·Annals of Pediatric Endocrinology & Metabolism·Yun Jeong LeeChoong Ho Shin
Feb 6, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Aysun AtaDamla Gökşen
May 1, 2021·Pediatric Diabetes·Anna-Lena FuremanUlf Samuelsson
Jul 18, 2021·Scientific Reports·Yun Jeong LeeJae Hyun Kim
Oct 31, 2021·Pediatric Diabetes·Marco MariglianoUNKNOWN SWEET Study Group