Body mass index was associated with upstaging and upgrading in patients with low-risk prostate cancer who met the inclusion criteria for active surveillance

Urologic Oncology
Ottavio de CobelliMatteo Ferro

Abstract

Obesity is associated with an increased risk of high-grade prostate cancer (PCa). The effect of body mass index (BMI) as a predictor of progression in men with low-risk PCa has been only poorly assessed. In this study, we evaluated the association of BMI with progression in patients with low-risk PCa who met the inclusion criteria for the active surveillance (AS) protocol. We assessed 311 patients who underwent radical prostatectomy and were eligible for AS according to the following criteria: clinical stage T2a or less, prostate-specific antigen level < 10 ng/ml, 2 or fewer cores involved with cancer, Gleason score ≤ 6 grade, and prostate-specific antigen density < 0.2 ng/ml/cc. Reclassification was defined as upstaged (pathological stage > pT2) and upgraded (Gleason score ≥ 7; primary Gleason pattern 4) disease. Seminal vesicle invasion, positive lymph nodes, and tumor volume ≥ 0.5 ml were also recorded. We found that high BMI was significantly associated with upgrading, upstaging, and seminal vesicle invasion, whereas it was not associated with positive lymph nodes or large tumor volume. At multivariate analysis, 1 unit increase of BMI significantly increased the risk of upgrading, upstaging, seminal vesicle invasion, and an...Continue Reading

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Citations

Jan 30, 2016·Urologic Oncology·Maximilien C Goris GbenouRoland van Velthoven
Sep 15, 2016·Future Oncology·Matteo FerroOttavio De Cobelli
Oct 25, 2016·European Urology·Adriana C Vidal, Stephen J Freedland
Jun 21, 2017·Current Opinion in Urology·Marco BandiniAlberto Briganti
May 16, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sergio A A SantosLuis A Justulin
Jan 26, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Pablo S SierraDavid Jarrard
Feb 10, 2019·Journal of Clinical Medicine·Yu Seob Shin, Jong Kwan Park
Apr 16, 2019·Expert Review of Molecular Diagnostics·Giuseppe LucarelliMichele Battaglia
Apr 9, 2019·Expert Review of Molecular Diagnostics·Giuseppe LucarelliMichele Battaglia
Apr 26, 2017·The Journal of Urology·Alexis R Freedland, Stephen J Freedland
Aug 28, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mariah FarrellMichaela R Reagan
Apr 4, 2021·International Journal of Molecular Sciences·Luca De ToniAndrea Garolla

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