Body Position Influences Which Neural Structures Are Recruited by Lumbar Transcutaneous Spinal Cord Stimulation

PloS One
Simon M DannerKaren Minassian

Abstract

Transcutaneous stimulation of the human lumbosacral spinal cord is used to evoke spinal reflexes and to neuromodulate altered sensorimotor function following spinal cord injury. Both applications require the reliable stimulation of afferent posterior root fibers. Yet under certain circumstances, efferent anterior root fibers can be co-activated. We hypothesized that body position influences the preferential stimulation of sensory or motor fibers. Stimulus-triggered responses to transcutaneous spinal cord stimulation were recorded using surface-electromyography from quadriceps, hamstrings, tibialis anterior, and triceps surae muscles in 10 individuals with intact nervous systems in the supine, standing and prone positions. Single and paired (30-ms inter-stimulus intervals) biphasic stimulation pulses were applied through surface electrodes placed on the skin between the T11 and T12 inter-spinous processes referenced to electrodes on the abdomen. The paired stimulation was applied to evaluate the origin of the evoked electromyographic response; trans-synaptic responses would be suppressed whereas direct efferent responses would almost retain their amplitude. We found that responses to the second stimulus were decreased to 14%±5% ...Continue Reading

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Citations

Aug 18, 2017·Physiology·Aiva Ievins, Chet T Moritz
May 23, 2018·Journal of Neurotrauma·Mrinal RathDimitry G Sayenko
Oct 27, 2018·Journal of Neurotrauma·Dimitry G SayenkoYury P Gerasimenko
Dec 28, 2018·The European Journal of Neuroscience·Jakob ŠkarabotRade Durbaba
Dec 21, 2019·Neurorehabilitation and Neural Repair·Alvaro Megía GarcíaJulio Gómez-Soriano
Nov 21, 2019·Journal of Neurophysiology·Trevor S BarssVivian K Mushahwar
Dec 24, 2018·Frontiers in Physiology·Dimitry G SayenkoYury P Gerasimenko
Sep 9, 2021·The European Journal of Neuroscience·Álvaro Megía-GarcíaJulio Gómez-Soriano
Nov 28, 2021·Journal of Clinical Medicine·Christina Salchow-HömmenNikolaus Wenger

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