Body surface area-based omega-3 fatty acids supplementation strongly correlates to blood concentrations in children.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
L LjungbladP Kogner

Abstract

Omega-3 fatty acids have been suggested as a complement in cancer treatment, but doses are not established. We performed a dose-finding study in 33 children in remission from cancer. Participants were allocated to a body surface area (BSA) adjusted dose (mg/m2) of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (40:60), ranging 233-3448 mg/m2 daily for 90 days. Fatty acid concentration in plasma phospholipids and red blood cells were determined by GC. Supplementation was well tolerated and correlated strongly with blood ω3-fatty acid concentrations and EPA showed the highest increase. Using the ω3-index disregards docosapentaenoic acid (DPA), which increased 30-43% in our study motivating an EDD-index (∑EPA,DPA,DHA). The ratio between arachidonic acid and EPA or DHA showed negative exponential trends. Dose per BSA enabled an individualized omega-3 supplementation decreasing the variation referred to interindividual differences. Based on our results, we suggest a dose of 1500 mg/m2 BSA for further studies.

References

Oct 22, 1987·The New England Journal of Medicine·R D Mosteller
Feb 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H W SprecherB S Mohammed
Jul 16, 2004·CA: a Cancer Journal for Clinicians·Kevin C Oeffinger, Melissa M Hudson
Dec 15, 2005·International Journal of Cancer. Journal International Du Cancer·Magnus LindskogJohn Inge Johnsen
Feb 28, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·William S Harris
Jan 30, 2009·The British Journal of Nutrition·Susanne ErikssonBirgitta Strandvik
Nov 6, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Helena GleissmanPer Kogner
May 26, 2010·International Journal of Cancer. Journal International Du Cancer·Helena GleissmanPer Kogner
Jul 27, 2010·Progress in Lipid Research·Gunveen KaurAndrew J Sinclair
Oct 26, 2010·Biochemical and Biophysical Research Communications·Chandi Charan MandalNandini Ghosh-Choudhury
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Oct 4, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Michael H Bloch, Ahmad Qawasmi
Jun 26, 2012·European Journal of Nutrition·Eliza MillerAndrew J Sinclair
Sep 26, 2013·Breast Cancer Research and Treatment·Md Mizanur RahmanGabriel Fernandes
Nov 21, 2013·Journal of the American Heart Association·Michael R FlockPenny M Kris-Etherton
Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Karin LarssonPer-Johan Jakobsson
Sep 2, 2015·The Journal of Clinical Investigation·Shabnam Shalapour, Michael Karin
Dec 25, 2015·Nutrition and Cancer·Carolina de Quadros CamargoErasmo Benicio Santos de Moraes Trindade
Jan 29, 2016·Journal of Clinical Medicine·Donatella D'Eliseo, Francesca Velotti
Feb 10, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Birgitta StrandvikKarl-Göran Sabel
Nov 3, 2016·Journal of Neurophysiology·Christopher M Filley, R Douglas Fields
May 19, 2017·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Janie AllaireBenoît Lamarche
Jun 13, 2017·Prostaglandins & Other Lipid Mediators·Trond Vidar HansenCharles N Serhan
May 8, 2018·The Journal of Clinical Investigation·Dingzhi Wang, Raymond N DuBois
Jun 23, 2018·The American Journal of Clinical Nutrition·J Thomas BrennaYu-Hong Lin
Dec 24, 2018·Journal of Lipid Research·Adam H MetherelRichard P Bazinet

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