PMID: 2097169Jan 1, 1990Paper

Body temperature rhythms, cold tolerance, and fever in young and old rats of both genders

Experimental Gerontology
R RefinettiE Satinoff

Abstract

The circadian rhythm of body temperature (CTR) of male and female rats living at 23 degrees C, as well as their body temperature response to a yeast injection or to a 2-h exposure to 0 degree C, was investigated by telemetry. Young rats had a clear CTR with a mean nocturnal peak of 38.0 +/- 0.1 degree C and diurnal trough of 36.2 +/- 0.1 degree C. Older rats, starting at about 18 months of age, tended to have poor (that is, lower amplitude) rhythms. Mean daily body temperature was 37.1 +/- 0.2 degree C at all ages. After exposure to the cold, the body temperature of young rats, old rats with a strong CTR, and old rats with a poor CTR changed in the ranges of -0.3 to +1.5 degree C, -3.1 to +0.7 degree C, and -5.2 to +0.4 degree C, respectively. This indicates that old animals, especially but not exclusively those with poor CTRs, are less resistant to cold stress. On the other hand, the capacity to develop a fever in response to a yeast injection was equivalent in the three groups of animals, although females had a smaller response than males. It is concluded that the process of aging does not have a generalized debilitating effect on temperature regulation in rats. Rather, aging seems to affect individual components of the therm...Continue Reading

References

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Citations

Mar 1, 1992·Physiology & Behavior·R Refinetti, M Menaker
Aug 1, 1995·Physiology & Behavior·C C BarneyK W Meeuwsen
Jul 1, 1995·European Journal of Pharmacology·S OhdoJ G Song
Jan 1, 1997·Life Sciences·N OgawaS Higuchi
Jun 17, 1998·Life Sciences·S OhdoS Higuchi
Aug 27, 1999·Physiology & Behavior·E SatinoffC R Plata-Salamn
Mar 10, 2001·Journal of Thermal Biology·P R. KamermanA Fuller
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S ScaccianoceL Angelucci
Jun 18, 2002·Ageing Research Reviews·S R Pandi-PerumalD F Swaab
Jan 8, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christopher J Gordon
Feb 1, 1996·Journal of Neuroendocrinology·S M MartinQ J Pittman
Mar 11, 1998·Clinical and Experimental Pharmacology & Physiology·E Satinoff
Jul 22, 2009·Ageing Research Reviews·Dietmar Weinert
Oct 31, 2006·Physiology & Behavior·Dietmar Weinert, Jim Waterhouse
Aug 2, 2005·Journal of Neuroscience Methods·Jorgete TomazettiCarlos Fernando Mello
Oct 9, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jacopo P Mortola, Clement Lanthier
Jun 1, 1997·Journal of Biological Rhythms·M WachulecE Satinoff
Mar 10, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhixin ZhangXiaoyan Gao
Mar 6, 2002·Biological Research for Nursing·B J Holtzclaw
Aug 16, 2017·Annals of Biomedical Engineering·Simon A Bello, Christopher L Passaglia
Oct 29, 1998·The American Journal of Physiology·C R Plata-SalamánE Satinoff
Jun 7, 2000·Chronobiology International·D Weinert
Dec 29, 2020·Frontiers in Physiology·Elisavet ZagkleEdyta T Sadowska
Dec 1, 2020·Temperature : Multidisciplinary Biomedical Journal·Roberto Refinetti
Apr 18, 2021·Journal of Thermal Biology·Leonardo M T de RezendeThales N Prímola-Gomes
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·H Moltz

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