PMID: 7014301Jan 1, 1981Paper

Body weight, skeletal muscle morphology, and enzyme activities in relation to fasting serum insulin concentration and glucose tolerance in 48-year-old men

Diabetes
H LithellB Saltin

Abstract

Tissue samples were taken from the gastrocnemius muscle of 26 randomly selected, glucose-tolerant, 48-yr-old men. Hexokinase, phosphorylase, lactate dehydrogenase (LDH), succinate dehydrogenase, and lipoprotein lipase activity (LPLA), as well as the area per fiber type and capillary density, were determined. Mean fiber area correlated positively with relative body weight (r equals 0.53, P less than 0.01), but capillary density did not. The result is that, in cases of high body weight, each capillary supplies a larger muscle fiber area. Serum insulin concentration in the fasting state correlated positively with body weight (r equals 0.77, P less than 0.001) and with mean fiber area per capillary (r equals 0.87; P less than 0.001). Only during the latter part of an oral glucose tolerance test (OGTT) did blood glucose concentrations correlate with relative body weight and mean fiber area per capillary (r equals 0.42, r equals 0.51, P less than 0.05). A stepwise multiple regression analysis showed that the different muscle morphology measurements could account for 3/4 of the variation in the fasting serum insulin concentration, the fasting insulin/glucose ratio, and the blood glucose concentration at 120 min in the OGTT. Of the int...Continue Reading

Citations

Oct 1, 1994·Diabetes/metabolism Reviews·G H Tomkin, D Owens
Dec 1, 1995·Diabetologia·H Yki-Järvinen
Jan 1, 1984·European Journal of Applied Physiology and Occupational Physiology·B KiensB Vessby
Aug 1, 1987·Baillière's Clinical Endocrinology and Metabolism·M R Taskinen, T Kuusi
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·E VillaR García-Robles
Jul 11, 2001·Trends in Endocrinology and Metabolism : TEM·T A AbduR N Clayton
Aug 9, 2002·Acta Physiologica Scandinavica·A HedmanH O Lithell
Apr 1, 1993·European Journal of Clinical Investigation·B RichelsenJ D Børglum
May 1, 1982·Acta Physiologica Scandinavica·G GrimbyB Saltin
Apr 1, 1992·Acta Physiologica Scandinavica·A Holmäng, P Björntorp
Jul 30, 2010·Journal of Atherosclerosis and Thrombosis·Sanae TanakaTsutomu Kazumi
Apr 20, 2014·Physiological Reports·Maxwell S DeniesScott Medler
Aug 11, 2006·Current Opinion in Cardiology·Behzad MolaviPhilip A Kern
May 5, 1998·Journal of Internal Medicine·T EndreU L Hulthén
Dec 1, 1984·Clinical Physiology·S P WoodhouseM R Belcher
Feb 1, 1983·European Journal of Clinical Investigation·M KrotkiewskiK Mandroukas
Aug 1, 1981·European Journal of Clinical Investigation·B KiensB Vessby
Sep 20, 2002·Journal of Atherosclerosis and Thrombosis·Naoko ShonoHiroaki Tanaka
Jun 1, 1994·Journal of the American College of Nutrition·B HennigC J McClain
Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·T PollareH Lithell
Aug 1, 1988·Diabetes/metabolism Reviews·S Lillioja, C Bogardus
Dec 22, 1999·The American Journal of Physiology·X M SongJ R Zierath
Dec 20, 2002·Obesity Research·Chamindie PunyadeeraIan Peter Gray
Jan 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·B VessbyH Lithell
Dec 22, 1999·The American Journal of Physiology·D E KelleyJ A Simoneau

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.