Body weight status and onset of cognitive impairment among U.S. middle-aged and older adults

Archives of Gerontology and Geriatrics
Xiaoling Xiang, Ruopeng An

Abstract

To examine the relationship between body weight status and onset of cognitive impairment among U.S. middle-aged and older adults. Study sample came from 1996 to 2010 waves of the Health and Retirement Study, consisting of 6739 community-dwelling adults born between 1931 and 1941 who were free from cognitive impairment in 1996. Body mass index (BMI) was calculated from self-reported height/weight. Cognitive impairment was defined by a composite score of 11 or lower on the immediate and delayed word recall, serial 7's, and backwards counting tests. Kaplan-Meier estimator and Cox proportional hazards model were performed to examine the association between base-year body weight status and future onset of cognitive impairment. Compared with their normal weight counterparts, the unadjusted hazard ratio (HR) for cognitive impairment incidence was 2.03 (95% confidence interval: 1.38-3.00), 1.15 (1.02-1.29), 1.28 (1.14-1.43), and 1.59 (1.33-1.92) among underweight (BMI<18.5), overweight (25 ≤ BMI < 30), class I obese (30 ≤ BMI < 35), and class II obese or above (BMI ≥ 35) participants, respectively. The unadjusted relationship between obesity and cognitive impairment onset appeared stronger among females than among males. After adjustin...Continue Reading

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Citations

Apr 15, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Roshan GunathilakeJohn Attia
Feb 13, 2016·PloS One·Sujin KimSang Min Park
Nov 2, 2018·Journal of Nutritional Science and Vitaminology·Hsing-Chun LinJeng-Yuan Chiou
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Oct 23, 2020·American Journal of Alzheimer's Disease and Other Dementias·Lian LiuYanqing Wu
Mar 6, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Hrafnhildur EymundsdottirMilan Chang

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