Body weight-supported training in Becker and limb girdle 2I muscular dystrophy

Muscle & Nerve
Bente R JensenJohn Vissing

Abstract

We studied the functional effects of combined strength and aerobic anti-gravity training in severely affected patients with Becker and Limb-Girdle muscular dystrophies. Eight patients performed 10-week progressive combined strength (squats, calf raises, lunges) and aerobic (walk/run, jogging in place or high knee-lift) training 3 times/week in a lower-body positive pressure environment. Closed-kinetic-chain leg muscle strength, isometric knee strength, rate of force development (RFD), and reaction time were evaluated. Baseline data indicated an intact neural activation pattern but showed compromised muscle contractile properties. Training (compliance 91%) improved functional leg muscle strength. Squat series performance increased 30%, calf raises 45%, and lunges 23%. Anti-gravity training improved closed-kinetic-chain leg muscle strength despite no changes in isometric knee extension strength and absolute RFD. The improved closed-kinetic-chain performance may relate to neural adaptation involving motor learning and/or improved muscle strength of other muscles than the weak knee extensors. Muscle Nerve 54: 239-243, 2016.

References

Sep 1, 1995·American Journal of Physical Medicine & Rehabilitation·C M McDonaldD D Kilmer
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Jan 12, 2001·Journal of the American College of Cardiology·H TanakaD R Seals
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Sep 9, 2008·Brain : a Journal of Neurology·Marie Louise SveenJohn Vissing
Apr 2, 2014·Neuromuscular Disorders : NMD·Martin Peter BerthelsenBente Rona Jensen

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Citations

Sep 1, 2017·Exercise and Sport Sciences Reviews·Matthew C Kostek, Bradley Gordon
Jul 24, 2018·Current Opinion in Neurology·Nicolai Preisler, Mette Cathrine Orngreen
Oct 28, 2019·The Physician and Sportsmedicine·Giuseppe LanzaMaria Bellomo
Dec 7, 2019·The Cochrane Database of Systematic Reviews·Nicoline Bm VoetAlexander Ch Geurts
Dec 22, 2020·Wiener klinische Wochenschrift·Agnieszka Sobierajska-RekJolanta Wierzba

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