Body Weight Variability Increases Dementia Risk Among Older Adults: A Nationwide Population-Based Cohort Study.

Frontiers in Endocrinology
Eun RohHye Jin Yoo

Abstract

Background: Recent growing evidences suggest that body weight (Bwt) variability, a repeated loss and regain of weight within a specific period, causes metabolic disturbances and can be a marker for poor homeostasis. Although there have been many studies about the association between Bwt variability and various health status, its association with the incidence of dementia among elderly people has not been examined. Methods: We performed a retrospective elderly cohort study from 19,987 participants with mean age 73 years old in the Korean National Health Insurance Service. We examined the risk of incident dementia, including Alzheimer's dementia and vascular dementia, according to the quartile of Bwt variability, represented as coefficient of variation (Bwt-CV), SD (Bwt-SD), and variability independent of the mean (Bwt-VIM). Results: In fully adjusted model, the group with the highest Bwt variability (Bwt-VIM Q4) showed an increased risk of all-cause dementia (hazard ratio [HR] 1.39, 95% confidence interval [CI] 1.206-1.603) and Alzheimer's dementia (HR 1.46, CI 1.240-1.724) compared to the lowest quartile (Bwt-VIM Q1). We also found that subjects with the highest Bwt variability (Q4) and underweight BMI had a significantly incre...Continue Reading

References

Jun 27, 1991·The New England Journal of Medicine·L LissnerK D Brownell
Dec 1, 1993·The American Journal of Clinical Nutrition·K van der KooyJ G Hautvast
Jan 1, 1998·The New England Journal of Medicine·J StevensJ L Wood
Jan 15, 2003·Neurology·F NourhashémiUNKNOWN PAQUID study. Personnes Agées Quid
Nov 24, 2004·Neurology·D GustafsonI Skoog
Oct 12, 2005·Archives of Neurology·Miia KivipeltoAulikki Nissinen
Mar 21, 2006·NeuroImage·Nicola PannacciulliPietro A Tataranni
Sep 22, 2006·Nature·G J MortonM W Schwartz
Nov 30, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J-P MontaniA G Dulloo
Apr 14, 2007·Current Alzheimer Research·Rachel A WhitmerKristine Yaffe
Oct 31, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A-C VergnaudS Czernichow
Mar 11, 2009·Archives of Neurology·Annette L FitzpatrickJosé A Luchsinger
Apr 24, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alice M ArnoldStephen Kritchevsky
Apr 9, 2010·Brain : a Journal of Neurology·Tom den HeijerMonique M B Breteler
Aug 10, 2010·Annals of Neurology·Stéphanie DebetteSudha Seshadri
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Nov 4, 2011·Nature Reviews. Neuroscience·Berislav V Zlokovic
Apr 12, 2013·Neurology·Ramit Ravona-SpringerUri Goldbourt
Jul 22, 2014·Journal of Korean Medical Science·You Joung KimKi Woong Kim
Dec 20, 2016·Journal of the American Geriatrics Society·Erin S LeBlancUNKNOWN Study of Osteoporotic Fractures (SOF) Research Group
Jul 6, 2017·The New England Journal of Medicine·Tim Christen, Renée de Mutsert
Jul 12, 2017·The New England Journal of Medicine·Lingjie Xu, Dongze Li
Sep 26, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Archana Singh-ManouxMika Kivimaki
Nov 24, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mika KivimäkiMarkus Jokela

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Tapan BehlSimona Bungau
Jun 20, 2021·American Journal of Preventive Medicine·Rui ZhouXian-Bo Wu
Aug 5, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·You-Bin LeeJae Hyeon Kim
Sep 11, 2021·Journal of Obesity & Metabolic Syndrome·Eun Mi Bae, Sang Min Park
Sep 16, 2021·Journal of Obesity & Metabolic Syndrome·Yong-Ho Lee
Dec 16, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hui ChenChangzheng Yuan

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