Boiled coffee fails to raise serum cholesterol in hamsters and rats

The British Journal of Nutrition
A C BeynenMartijn B Katan

Abstract

Boiled coffee contains the lipid compounds cafestol and kahweol, which raise cholesterol strongly in man. These lipids are retained by paper filters. In a search for an animal model for the effect of coffee lipids on serum cholesterol concentrations, we fed hamsters (Mesocricetus auratus) and rats on mash diets consisting of a purified base diet and either boiled water, unfiltered boiled coffee or filtered boiled coffee. After a feeding period of 8 weeks there was no statistically significant effect of unfiltered boiled coffee on serum total cholesterol and triacylglycerol concentrations in either the hamsters or the rats. The level of serum cholesterol did respond predictably to the addition of cholesterol and/or saturated fatty acids to the diet. The lack of effect of unfiltered boiled coffee in the hamsters and the rats, when compared with the previously reported activity in humans, could not be explained by dosage, duration of treatment, mode of administration or by insufficient statistical power. It is concluded that hamsters and rats are insensitive to unfiltered boiled coffee and thus are unsuitable models for investigating its hypercholesterolaemic effect.

References

Sep 1, 1992·The British Journal of Nutrition·T A Sanders, S Sandaradura
Mar 1, 1992·Zeitschrift für Ernährungswissenschaft·R P MensinkA C Beynen
Oct 1, 1991·Journal of Internal Medicine·I AholaA Aro
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M van DusseldorpA F Stalenhoef
Sep 1, 1990·International Journal of Epidemiology·P PietinenH Korhonen
Nov 23, 1989·The New England Journal of Medicine·A A Bak, D E Grobbee
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D K Spady, J M Dietschy
Nov 1, 1987·Metabolism: Clinical and Experimental·A AroP Pietinen
Jun 16, 1983·The New England Journal of Medicine·D S ThelleO H Førde

❮ Previous
Next ❯

Citations

Sep 27, 2000·The Journal of Nutritional Biochemistry·A H TerpstraA C Beynen
Dec 22, 1999·The Proceedings of the Nutrition Society·B de RoosL L Rudel
Jan 1, 1997·Annual Review of Nutrition·R Urgert, M B Katan
Mar 29, 2002·Kidney International·Stevan P TofovicSheldon I Bastacky
Oct 3, 2012·Cell Biochemistry and Function·Gianella CaiozziMarie-Louise Ricketts
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·S M PostH M Princen
Jul 22, 2006·Toxicological Reviews·Isabella M Rodrigues, Laura C Klein
Mar 21, 1998·Current Opinion in Lipidology·C A Hassel
Jun 11, 2020·Food Research International·Marzieh Moeenfard, Arminda Alves

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.